A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

By Hadas Keren-Shaul, A. Spinrad, A. Weiner, Orit Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K. Ulland, Eyal David, Kuti Baruch, David Lara-Astaiso, Beáta Tóth and 4 more. Cell, 2017

4,629 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/212eb732533a5fd49e8706b1400b83aa51ea9f89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Ransohoff
2. D. Holtzman
3. J. Long
4. O. Butovsky
5. Beth Stevens
6. Chao Gao
7. Shengdi Chen
8. Yuyan Tan

In Neurology

1. R. Ransohoff
2. D. Holtzman
3. J. Long
4. Beth Stevens
5. Chao Gao
6. Shengdi Chen
7. Yuyan Tan
8. Jingwen Jiang

In Physiology

1. J. Long
2. D. Holtzman
3. R. Ransohoff
4. E. Karran
5. B. de Strooper
6. Bradley T. Hyman
7. T. Wyss‐Coray
8. Henrik Zetterberg

Citations in the corpus

• Spatial components of molecular tissue biology (2022, positive): “Advances in single-cell profiling have highlighted the aberrations in cell states, compositions and interactions that are associated with disease onset, progression or response to therapy 83,84 and have begun to delineate the coordinated changes across them 34,35 .”
• The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019, background): “We demonstrate here, in agreement with previous findings (Keren-Shaul et al., 2017; Krasemann et al., 2017), that ARMs induce Apoe expression up to 27-fold, compared to homeostatic microglia.”
• Single cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes (2018, background): “These markers may comprise elements of a common activation pathway, since these genes are also upregulated in microglia that surround plaques in an Alzheimer’s disease model (Keren-Shaul et al., 2017).”
• Microglia states and nomenclature: A field at its crossroads (2022, neutral): “58,59,85,121 How the TREM2 receptor drives the DAM transcriptional phenotype remains unclear, although the TREM2-ApoE signaling pathway is necessary for the switch from homeostatic to MGnD. 59 Further investigations are required to fully elucidate the role of TREM2.”