Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.

By T. Camenisch, A. Spicer, T. Brehm-Gibson, J. Biesterfeldt, M. L. Augustine, A. Calabro, S. Kubalak, S. Klewer, J. McDonald. Journal of Clinical Investigation, 2000

891 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9cb47225868225e6c0aeff4c4793981478309772

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Citations in the corpus

Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “The combination of tensile resistance due to collagen and compression compliance due to hyaluronic acid creates the ideal biophysical properties for tissue homeostasis [145].”
Hyaluronan as an Immune Regulator in Human Diseases (2011, positive): “5 completely lack endocardial cushions (46, 47), consistent with early observations that a high content of HA is present in normal human heart valves (464).”
Cardiac chamber formation: development, genes, and evolution. (2003, background): “Hyaluronan synthetase-2-deficient mouse embryos are unable to produce hyaluronan, an important component of cardiac jelly (37).”
Glycosaminoglycans and their proteoglycans: host‐associated molecular patterns for initiation and modulation of inflammation (2006, background): “Hyaluronan synthase 1 (HAS1) Viable (39) Hyaluronan synthase 2 (HAS2) Embryonic lethal, cardiac and vascular abnormalities (49)”
The mammalian ovary from genesis to revelation. (2009, background): “null mice are embryonic lethal (335), but RNA interfer-”
Regulation of lung injury and repair by Toll-like receptors and hyaluronan (2005, background): “Overexpression of high-molecular-mass hyaluronan To more directly examine the role of hyaluronan in regulating the repair of lung injury in vivo , we generated transgenic mice that constitutively express hyaluronan synthase 2 (HAS2, encoded by Has2”
Hyaluronan: from extracellular glue to pericellular cue (2004, background): “Analyses of Has2 -null mice have shown severe defects in morphogenesis, especially in cardiac development, that lead to embryonic lethalit”
The Extracellular Matrix In Development and Morphogenesis: A Dynamic View (2009, background): “Thus, the regulated expression of hyaluronan synthases and other enzymes involved in GAG assembly can have important developmental consequences (Camenisch et al., 2000; Spicer et al., 2002).”
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer (2015, background): “Importantly, Has2 null mice fail to synthesize HA during cardiac cushion development, and the endothelial cushion cells do not undergo mesenchymal transformation (EMT) and cannot form the underlying connective tissue, which leads to midgestational death (5, 46).”
Hyaluronan in tissue injury and repair. (2007, background): “F or p er so na l u se o nl y. (Camenisch et al. 2000), resembling the features in naturally occurring versican knockouts.”
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. (2001, background): “Tie2-Cre transgenic mice can provide valuable informaion regarding the roles of molecules which may be inolved with the endocardial–mesenchymal transformation n vivo (Camenisch et al., 2000).”
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. (2010, background): “(60) have shown that in embryos deficient for Has2, an enzyme responsible for HA synthesis, endocardial cells overlaying the cardiac cushion forming area display reduced EMT and migration (60), a phenotype rescued by a constitutively active Ras.”