Hyaluronan in tissue injury and repair.

By D. Jiang, Jiurong Liang, P. Noble. Annual Review of Cell and Developmental Biology, 2007

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A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides (2010, background): “In the ECM of vertebrates, a linear and structurally simple polysaccharide such as hyaluronan, a polymer of repeating disaccharides of D-glucuronic acid and D-N-acetylglucosamine linked via alternating β-1,4 and β-1,3 glycosidic bonds, contributes in maintaining cell and tissue integrity as well as ”
Hyaluronic Acid in the Third Millennium (2018, background): “However, HAS gene sequences are located on different chromosomes (hCh19-HAS1, hCh8-HAS2 and hCh16-HAS3) [91,92], and the expression and the activity of HAS isoforms are controlled by growth factors, cytokines and other proteins such as kinases in different fashions, which appear cell and tissue spec”
Sterile inflammation: sensing and reacting to damage (2010, background): “Hyaluronan fragments, for example, can signal through CD44, leading to MAPK activatio”
Macrophage activation by endogenous danger signals (2008, background): “This later signalling response is thought to mediate the inflammatory response of innate immune cells to hyaluronan fragments [64].”
Origin and physiological roles of inflammation (2008, background): “This conversion is also thought to be ROS dependen”
Hyaluronan as an Immune Regulator in Human Diseases (2011, neutral): “ing their cell secretory and behavioral properties (187).”