The Extracellular Matrix In Development and Morphogenesis: A Dynamic View

By Tania Rozario, D. DeSimone. Developmental Biology, 2009

1,387 citations recorded by the source corpus.

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of development. Our understanding of ECM composition, structure and function has grown considerably in the last several decades and this knowledge has revealed that the extracellular microenvironment is critically important for cell growth, survival, differentiation and morphogenesis. ECM and the cellular receptors that interact with it mediate both physical linkages with the cytoskeleton and the bidirectional flow of information between the extracellular and intracellular compartments. This review considers the range of cell and tissue functions attributed to ECM molecules and summarizes recent findings specific to key developmental processes. The importance of ECM as a dynamic repository for growth factors is highlighted along with more recent studies implicating the 3-dimensional organization and physical properties of the ECM as it relates to cell signaling and the regulation of morphogenetic cell behaviors. Embryonic cell and tissue generated forces and mechanical signals arising from ECM adhesion represent emerging areas of interest in this field.

Subfields: Cell Biology, Genetics, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/eeb5dba67427222dfbcfbf1adce66756edec97ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Alexandra Naba
2. E. Mojares
3. Cameron G Walker
4. Armando E. del Río Hernández
5. Steven A. Carr
6. Valerie M. Weaver
7. Karl R. Clauser
8. R. Hynes

In Genetics

1. E. Mojares
2. Cameron G Walker
3. Armando E. del Río Hernández
4. Valerie M. Weaver

In Immunology and Allergy

1. Alexandra Naba
2. E. Mojares
3. Cameron G Walker
4. Armando E. del Río Hernández
5. Steven A. Carr
6. Valerie M. Weaver
7. Karl R. Clauser
8. R. Hynes

Citations in the corpus

• Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “As it binds to discoidin domain receptors (DDRs) expressed by mammary gland cells, it prevents hyper-proliferation possibly to maintain the tubular structure [87,101].”
• Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size (2013, neutral): “178 181 The ultimate aim of tissue scaffolding strategies is to mimic the actual 3D microenvironment that is the ECM.”
• Overview of the matrisome--an inventory of extracellular matrix constituents and functions. (2012, background): “As mentioned above and elsewhere (Hynes 2009; Ramirez and Rifkin 2009; Rozario and DeSimone 2010), many growth factors bind to ECM proteins and must be considered also as constituents of extracellular matrices.”
• The extracellular matrix at a glance (2010, background): “FN is also important for cell migration during development and has been implicated in cardiovascular disease and tumor metastasis (Rozario and DeSimone, 2010; Tsang et al., 2010).”
• The Extracellular Matrix: Tools and Insights for the “Omics” Era (2015, background): “Extracellular matrix proteins provide biochemical cues interpreted by cell surface receptors, such as the integrins [6] and initiate signaling cascades controlling cell survival, cell proliferation, differentiation and stem cell state [7,8].”