Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.

By Y. Kisanuki, Robert E. Hammer, J. Miyazaki, Clay K. Williams, James A. Richardson, M. Yanagisawa. Developmental Biology, 2001

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Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “To delete Vegfa in macrophages, we crossed floxed Vegfa (Vegfafl/fl) mice (Gerber et al., 1999) with mice carrying the Tie2-Cre transgene (Kisanuki et al., 2001) or the knock-in LysmCre (Clausen et al., 1999).”
Essential roles of Meltrin β (ADAM19) in heart development (2004, background): “Because endocardial cushion mesenchymes essen- tially originate from endocardial epithelial cells in the AV and conus cushion (Kisanuki et al., 2001), Neuregulin that is produced before EMT can be a substrate of Meltrin h, both in the epithelia and in the mesenchymes after EMT.”
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, methodology): “Although some success has been achieved using the Cre-LoxP genetic system (Herrera, 2000; Kimmel et al., 2000; Kisanuki et al., 2001; Rodriguez et al., 2000), one drawback of the system in its simplest form is that cells are marked from the time when the promoter driving Cre expression is first…”