Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

By L. Luttrell, F. L. Roudabush, E. W. Choy, W. Miller, M. Field, K. L. Pierce, R. J. Lefkowitz. Proceedings of the National Academy of Sciences of the United States of America, 2001

899 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c9f64e2f6961dd90e0900e8d161a59e7b7150c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. Sudha K. Shenoy
2. R. J. Lefkowitz
3. Walter Kolch
4. R. Roskoski

In Molecular Biology

1. R. J. Lefkowitz
2. Éric Reiter
3. Sudha K. Shenoy
4. R. Roskoski
5. M. von Zastrow
6. Seungkirl Ahn
7. S. Rajagopal
8. Walter Kolch

Citations in the corpus

• β-Arrestins and Cell Signaling (2007, background): “Previously, studies of β-arrestin signaling generally relied on overexpression of β-arrestins in cell lines, such as COS-7, with very low endogenous β-arrestin expression (50, 53).”
• GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling (2006, background): “Similarly, b-arrestins simultaneously interact with Raf (MAPKKK), MEK1 (MAPKK) and ERK (MAPK) [40, 41 ].”
• Differential regulation and properties of MAPKs (2007, background): “…protein p14, where it promotes the formation and activation of ERK complexes in response to EGF (Teis et al., 2002). b-Arrestins 1 and 2 function as scaffolds to enhance Raf-1 and MEK-dependent activation of ERK1/2, and direct the activated ERK1/2 into endosomal vesicles (Luttrell et al., 2001).”
• Teaching old receptors new tricks: biasing seven-transmembrane receptors (2010, background): “org/DATABASE/ObjectDisplayForward?objectId=34">AT 1A ) receptor results in the formation of a β-arrestin 2, RAF1, MAPK/ERK kinase (MEK1) and ERK1/2 signalling comple”
• Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling (2003, background): “Another G α q -coupled receptor that can engage β -arrestin/ Raf/MEK/ERK scaffolds in the cytoplasm is the AT 1A R [95].”
• The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. (2002, background): “results have been obtained for the angiotensin II type 1a (AT1a) receptor expressed in HEK293 and COS-7 cells (Luttrell et al., 2001).”
• Coordinating ERK/MAPK signalling through scaffolds and inhibitors (2005, background): “At the same time, β-arrestin-2 mediates the activation of ERK/MAPK by assembling new signalling complexes comprising Raf-1, MEK and ERK/MAP”
• Seven-transmembrane-spanning receptors and heart function (2002, background): “2 ) is their role as adaptors or scaffolds that bring together elements of complex heptahelical-receptor-stimulated signalling pathways, and that facilitate the activation and subcellular localization of the signalling proteins involved in these pathway”
• ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “described an agonist-induced signaling complex that contained -arrestin2, C-Raf, MEK1, and ERK1/2 [146].”