ERK1/2 MAP kinases: structure, function, and regulation.
By R. Roskoski. Pharmacological Research, 2012
1,567 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d0d6f6c65e8b8c9f2aea10abb5adf7336a3fd11d
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Citations in the corpus
- Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases (2017, neutral): “ERK1/2 is a component of the Ras-Raf-MEK-ERK signaling cascade [49].”
- The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review) (2017, neutral): “Activation or deactivation of kinase occurs in different ways: through the kinase itself with a cis -phos- phorylation/autophosphorylation, by binding with activator or inhibitor proteins or checking their localization in the cell in relation to their substrate (7).”
- Leveraging implicit knowledge in neural networks for functional dissection and engineering of proteins (2019, background): “Strikingly, ERK2 catalytic and ATP-binding residues 25 could be precisely inferred from the sensitivity values alone (Fig.”
- The ErbB/HER family of protein-tyrosine kinases and cancer. (2014, background): “Ras GTPase activating protein (RasGAP) mediates Ras inactivation.”
- Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Interestingly, so far only cancers with mutant B-RAF V600G can be effectively treated with therapeutics [199].”
- ERK/MAPK signalling pathway and tumorigenesis (2020, background): “This review focuses on the ERK cascade (4-6) which involves several kinases in the MAP3K layer (mainly Rafs), including Ras/Raf/MAPK (MEK) 1/2 at the MAPKK layer, ERK1/2 at the MAPK layer and several MAPKAPKs in the next layer (ribosomal s6 kinases, MAP kinase-interacting serine/threonine-protein ki”