Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

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International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family (2009, background): “…angiotensin II type I A receptor and the V2 vasopressin receptor, -arrestins play the role of adaptors and scaffolding molecules that have recently emerged as signal transducers for the activation of ERK in response to agonist stimulation (Shenoy and Lefkowitz, 2003; Lefkowitz and Whalen, 2004).”
GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling (2006, background): “GRK-mediated phosphorylation and subsequent b-arrestin binding are essential to clathrin-dependent internalization [ 7 ].”
G Protein-Coupled Receptor Kinases (2016, background): “Proc Natl Acad Sci U S A 83(9):2797–2801 20.”
Desensitization of G protein-coupled receptors and neuronal functions. (2004, background): “Arrestins serve as adaptors to ferry a wide variety of signaling proteins to activated receptors, including c-Src, entire MAP kinase cascades, Mdm2, ARNO, NSF, and others (Gurevich & Gurevich 2003, Luttrell & Lefkowitz 2002, Shenoy & Lefkowitz 2003).”