Seven-transmembrane-spanning receptors and heart function

By H. Rockman, W. Koch, R. J. Lefkowitz. Nature, 2002

1,004 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Computational Theory and Mathematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a60533e3e2b4deb1be25ecc3a610e40683b797fa

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In Cardiology and Cardiovascular Medicine

In Computational Theory and Mathematics

R. J. Lefkowitz

In Molecular Biology

Citations in the corpus

Desensitization of G protein-coupled receptors and neuronal functions. (2004, background): “Over the past several years, we and others have developed mouse lines bearing deletions of each of the GRK and arrestin genes (Table 1 and references within), which we have used previously to characterize the GPCR regulation machinery in the heart (Rockman et al. 2002).”
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. (2010, background): “Heterotrimeric G proteins consist of three subunits (α, β and γ) and couple to GPCR. Binding of an agonist to the GPCR leads to dissociation of the Gα and Gβγ subunits, followed by activation of downstream signaling pathways (Gutkind, 1998a,b; Rockman et al., 2002).”
Protein kinase cascades in the regulation of cardiac hypertrophy. (2005, background): “Gq/phospholipase C and cross-talk with PI3K/Akt The heterotrimeric G-proteins Gq and G11 are functionally redundant transducers of phospholipase C signaling from prohypertrophic heptahelical receptors for angiotensin, endothelin, norepinephrine, and other neurohormones (34).”
Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development (2004, background): “Elevation of cyclic AMP in response to -adrenergic agonists also stimulates cardiac hypertrophy via protein kinase A and other downstream effectors (36).”
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. (2003, background): “Vasoactivators like angiotensin II, endothelin-1, and phenylephrine all activate G proteincoupled receptors, leading to cellular responses such as gene activation, protein synthesis, and an increase in cell size (Rockman et al. 2002).”
Phosducin‐like protein acts as a molecular chaperone for G protein βγ dimer assembly (2005, background): “Heterotrimeric G proteins mediate a wide array of hormonal, neuronal and sensory signals that control numerous physio- logical processes ranging from cardiac rhythm (Rockman et al, 2002) to psychological behavior (Gainetdinov et al, 2004) to vision (Arshavsky et al, 2002).”
G Protein-Coupled Receptor Kinases (2016, background): “Signal transduction is accomplished by the polarization of photoreceptor cells, which are composed of three major domains: (1) an outer segment which contains the membrane disks where the phototransduction machinery is localized, (2) an inner segment”
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II (2004, background): “The AT1 receptor is a guanine-nucleotide-binding protein (G-protein)-coupled receptor (GPCR), a member of a large family of cell-surface receptors that contain common structural features characterized by seven transmembrane helices essential for signal transductio”