Differential regulation and properties of MAPKs

By Malavika Raman, Wei Chen, M. Cobb. Oncogene, 2007

1,496 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f97576e6055743cf554d8b4c703839849d241b87

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Citations in the corpus

MAP kinase pathways. (2012, neutral): “1) (Qi and Elion 2005; Raman et al. 2007; Keshet and Seger 2010).”
ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “ERK1/2 are also activated by cytokines, osmotic stress, and activated seven transmembrane G-protein coupled receptors [11].”
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “The human MKK4 phosphorylation sites are Ser257 and Thr261, those for MKK7 are Ser206 and Thr210, those for MKK3 are Ser189 and Thr193, and those for MKK6 are Ser207 and Thr211 (44, 60, 71, 182, 201, 227, 229, 252, 293, 329, 343).”
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. (2010, background): “multitude of cellular settings and has been reviewed in great detail by others (31, 221, 318, 332, 333, 348).”
JNK Signaling in Apoptosis (2008, background): “While MKK4 can activate both p38MAPK and JNK, MKK7 is specifically involved in the activation of JNKs.”
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage. (2016, background): “programs including embryogenesis, pro-liferation, differentiation and apoptosis [36].”
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases (2011, background): “Additional transcription factors have been shown to be phosphorylated by JNK, including p53, ATF-2, NF-ATc1, Elk-1, HSF-1, STAT3, c-Myc, and JunB (31, 278), but very little is known about the contribution of each JNK family member to their regulation.”
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “59 Aberrant RAF activation or mutations in upstream activators such as RAS or receptor tyrosine kinases (RTKs) can contribute to the development of malignancies in humans.”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “The differences in activation of these two cascades, when existing, are mediated by speci ﬁ c scaffold proteins, compart-mentalization, and variable substrates [2,46,47].”
Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior (2011, background): “MAPK signaling is regulated by the kinetics of activation, nearby phosphatase activity, and the cellular domain the MAPKs occupy.(93) Initially, ERK MAPKs were shown to require receptor tyrosine kinase transactivation, through epidermal growth factor or brain derived neurotrophic factor (also called”