Coordinating ERK/MAPK signalling through scaffolds and inhibitors
By Walter Kolch. Nature reviews. Molecular cell biology, 2005
1,167 citations recorded by the source corpus.
Subfields: Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/c9a30e8b6afcf11a6beee3eccfb2da168e0da287
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Citations in the corpus
- Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, background): “A positive role for PP2A in Ras-mediated signaling can be explained by PP2A-mediated dephosphorylation of critical sites on both the scaffold proteins, KSR and Raf-1, facilitating their recruitment to the membrane (59, 100).”
- ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation (2008, background): “The RAS–ERK pathway triggers one of these cascades and governs many important functions, such as cell fate, differentiation, proliferation and survival in invertebrate and mammalian cell”
- The MEK/ERK cascade: from signaling specificity to diverse functions. (2007, background): “In addition, scaffold proteins can provide better stability to some of the cascade components, to determine the threshold of signaling and lead to different functions of a given cascade by recruiting of different substrates to individual cascade components [87,107,108].”
- ERK/MAPK signalling pathway and tumorigenesis (2020, background): “These regulatory factors affect bispecific phosphatases (7‑10), scaffold proteins (11-14), signal duration and intensity (15), and the dynamic subcellular localization of cascade components (16,17).”
- Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer (2007, background): “These include kinase suppressor of Ras 1 (KSR1), MEK partner-1 (MP1), b-arrestins, IQ motif-containing GTPase activating protein 1 (IQGAP1) and others (Kolch, 2005 ).”
- Signalling ballet in space and time (2010, neutral): “The function of scaffolds in other systems, such as the MAPK pathway, is increasingly being appreciated and was also recently reviewe”
- A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, background): “S8 and table S10), indicating that transmission of information through the core pathway is not resolvable with the available proteomics data covering time points of 1, 5, 10, and 20 min after EGF stimulation ( 5 , 8 ).”
- Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “…of MAPK pathway constituents may offer an alternative strategy MAPK accessory proteins are spatially assembled to promote cooperation during signaling 150 and can be divided into four categories: (1) anchoring proteins, (2) docking proteins, (3) adapter proteins, and (4) scaffold proteins (Fig.”
- Lysosomal membrane permeabilization in cell death (2008, background): “The molecular mechanism by which p38 MAPk regulates LMP and cell death remains elusive, although it may be related to p38 binding to lysosomes and endosomes through an interaction with p14 and MP1 proteins (Kolch, 2005).”
- ERK1/2 MAP kinases in cell survival and apoptosis (2006, background): “specific subcellular localizations, enhancing the signal flux and mediating cross-talk with other pathways ( 13 ).”
- Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. (2006, background): “Raf kinase is a member of a large protein complex that includes 14-3-3, RKIP, KSR, CNK, Spred, and SURB proteins (27, 28).”