Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

By S. Bruner, Derek P. G. Norman, G. Verdine. Nature, 2000

941 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9b4aae952729a7c99cdf8ca119e187640ceeb800

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Citations in the corpus

Oxidative DNA damage: mechanisms, mutation, and disease (2003, background): “The formation of 8-OH-Gua in situ in DNA results in an 8-OH-Gua:C pair that is a substrate for the well-characterized OGG1 protein (8oxoguanine glycosylase 1) (29), which, as the name suggests, liberates 8-OH-Gua via a glycolytic mechanism from double-stranded substrates, relying on an internal Lys ”
Sequence-Dependent Basepair Opening in DNA Double Helix (2006, background): “DNA damage repair enzymes, such as uracil DNA glycosylase (9,10), 8-oxoguanine DNA glycosylase I ( 11 ,12), and alkyl adenine DNA glycosylase (13) also utilize the baseflipping mechanism.”
Role of oxygen radicals in DNA damage and cancer incidence (2004, background): “The 8-oxoG lesion is important because it is relatively easily formed and is mutagenic, therefore is a potential biomarker of carcinogenesis [108].”
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). (2004, background): “glycosylase to discriminate between undamaged and oxidized guanine residues (41,42), suggesting that the purine N7 position may be a generally important landmark for the specificity of some DNA–protein interactions.”
Genome maintenance mechanisms for preventing cancer (2001, background): “has been resolved to the tertiary structure of all core component”
Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate (2003, background): “Mechanistically, DNA glycosylases that are involved in DNA repair share some similarities with TG”
Effluent from an NSAID-Manufacturing Plant in Mexico Induces Oxidative Stress on Cyprinus carpio (2013, background): “Also, ROS may affect the deoxyribose backbone and produce ruptures chain due to abstraction of a hydrogen sugar and phosphodiester bond rupture (Bruner et al. 2000; Miller et al. 2000).”
DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis. (2002, methodology): “4 kb of 5 -flanking DME genomic sequence ligated to a full-length DME cDNA (see Experimental Proce- nicking the DNA (Bruner et al., 2000; Jiricny, 2002).”
8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis (2009, background): “For the lesion 8-oxoG, the most important and relevant enzyme in mammalian cells is the Ogg1 protein, in which the gene was cloned (76, 77).”
Base-excision repair of oxidative DNA damage (2007, background): “These general features used for lesion recognition are well illustrated by the X-ray crystal structure of a catalytically inactive variant of OGG1 (in which the lysine residue at position 249 is replaced by a glutamine residue; Lys249Gln) bound to a substrate duplex containing an 8-oxoG·C base pai”