Base-excision repair of oxidative DNA damage

By S. David, Valerie L O'shea, Sucharita Kundu. Nature, 2007

1,212 citations recorded by the source corpus.

How researchers see this paper

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The DNA Damage Response: Making it safe to play with knives (2010, background): “The mechanism by which deficiency of MMR factors and MYH preferentially affects intestinal cells has not been determined.”
Redox Regulation of Cell Survival (2008, positive): “In contrast, excessive damage or failure in DNA repair can induce apoptosis (60).”
The DNA damage response and cancer therapy (2012, background): “In BER, damaged bases are first removed from the double helix, and the 'injured' section of the DNA backbone is then excised and replaced with newly synthesized DN”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “When compared to moderate levels of DNA damage that trigger cell cycle arrest and initiate DNA-repair processes to ensure DNA integrity, excessive damage in DNA repair can induce apoptosis [165].”
The DNA-damage response in human biology and disease (2009, neutral): “In base-excision repair, a damaged base is often recognized by a DNA glycosylase enzyme that mediates base removal before nuclease, polymerase and ligase proteins complete the repair 14 in processes overlapping with those used in SSB repair 15,16 .”