Oxidative DNA damage: mechanisms, mutation, and disease

By M. Cooke, M. Evans, M. Dizdaroglu, J. Lunec. The FASEB Journal, 2003

3,224 citations recorded by the source corpus.

Subfields: Inorganic Chemistry, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/39d06ed4e7665fd99aac5dc919b010f03da84bfa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Kundu
2. K. Rahman
3. J. Post
4. Y. Surh
5. J. Boonstra
6. Xia Zhang
7. Wei-Wei Chen
8. Wenjuan Huang

In Oncology

1. Y. Surh
2. J. Kundu
3. B. A. Hocevar
4. L. Kamendulis
5. J. Klaunig

Citations in the corpus

• Oxidative Stress in Aging Human Skin (2015, neutral): “[282].”
• Oxidative stress and autophagy: the clash between damage and metabolic needs (2014, neutral): “DNA–DNA intrastrand adducts, single-strand break (SSB), double-strand break (DSB) and DNA–protein crosslinks.(97,98)”
• Studies on free radicals, antioxidants, and co-factors (2007, background): “This damage to the DNA can result either in arrest or induction of transcription, induction of signal transduction pathways, replication errors, and genomic instability, all of which are associated with carcinogenesis (Marnett 2000; Cooke et al 2003).”
• Fluorescence probes used for detection of reactive oxygen species. (2005, background): “It is well known that the exposition to certain noxious factors, such as some xenobiotics, infectious agents, pollution, UV light, cigarette smoke and radiation, may lead to the production of ROS [5,6].”
• Drug-Induced Oxidative Stress and Toxicity (2012, background): “Several DNA glycosylases specifically recognize and remove 8-oxoGua in human cells, the primary being 8-oxoGua glycosylase (OGG1) [14].”
• Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “Once they are produced, ROS react with lipids, proteins, and nucleic acids causing oxidative damage to these macromolecules [30–34].”
• Oxidative Stress and Antioxidant Defense (2012, background): “Oxidation of 5-MeCyt to 5-hydroxymethyl uracil (5-OHMeUra) can occur via deamination/oxidation reactions of thymine or 5-hydroxymethyl cytosine intermediates.(107) In addition to the modulating gene expression, DNA methylation also seems to affect chromatin organization.”
• Inflammation: gearing the journey to cancer. (2008, background): “ROS-induced DNA damages including DNA strand breaks, DNA base modifications, and DNA cross-links result in the replication errors and the genomic instability and hence contribute to tumor initiation [19,20].”
• Mitochondrial Dysfunction in Parkinson's Disease (2011, background): “The ·OH radical has been shown to react with the double bond of DNA bases leading to damaging DNA lesions [35] and an impairment of normal cellular function.”