Genome maintenance mechanisms for preventing cancer

By Jan H. J. Hoeijmakers. Nature, 2001

4,155 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0f61e028e7f97375defc2b754e37345af93b400

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In Cell Biology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. C. Lukas
5. K. Gudmundsdottir
6. Yosef Shiloh
7. B. Kaina
8. Wolf-Dietrich Heyer

In Molecular Biology

1. Ryuji Hamamoto
2. Yusuke Nakamura
3. Stephen P. Jackson
4. N. Dohmae
5. Takehiro Suzuki
6. J. Bartek
7. J. Lukas
8. Lianhua Piao

Citations in the corpus

• UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. (2005, neutral): “as xeroderma pigmentosum (XP) and Cockayne syndrome (CS) [1, 2].”
• Checking on DNA damage in S phase (2004, background): “To cope with this challenging task, all eukaryotes have evolved an elaborate network of molecular mechanisms to detect unreplicated or aberrant DNA structures, to spread the alert signal, and to respond through the coordinated activities of diverse DNA-repair and so-called cell-cycle-checkpoint path”
• A TALE nuclease architecture for efficient genome editing (2011, methodology): “Moreover, cleavage-based genome engineering methods are portable to diverse cell types and species as the requisite repair pathways are highly conserve”
• The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “The eukaryotic cell has evolved several ways of repairing the multiple different types of DNA damage that occur (Hoeijmakers, 2001).”
• Mechanisms of human DNA repair: an update. (2003, background): “Historical aspects pertaining to the field of DNA repair have recently been highlighted (Friedberg, 2003) and several reviews on different areas of DNA repair appeared (Hoeijmakers, 2001; Lehmann, 2002; Lindahl, 2001; Svejstrup, 2002; 0300-483X/$ – see front matter © 2003 Elsevier Ireland Ltd.”
• Regulation of homologous recombination in eukaryotes (2010, background): “Defects in DNA repair proteins lead to various inherited human diseases sharing common features such as genome instability and cancer predisposition (71).”
• Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers (2002, background): “Elaborate DNA repair systems have evolved to eliminate DNA adducts from the genome (Hoeijmakers, 2001).”
• Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “Inherited defects in BRCA1 and BRCA2 strongly predispose individuals to breast cancer (255), while defects in BRCA1 also cause progeroid phenotypes in mice (84).”
• The genetics and genomics of cancer (2003, background): “19 ) and those involved in DNA mismatch repair (see below”