Positive and negative selection of T cells.

By T. Starr, S. Jameson, K. Hogquist. Annual Review of Immunology, 2003

1,744 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9aeada7a93aad338a7e52393f08ea272758d5d41

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Citations in the corpus

• T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse (2011, background): “For example, CD4+CD8+ double-positive (DP) thymocytes with low affinity for self-peptide MHC (pMHC) ligands undergo positive selection, whereas those with high affinity undergo negative selection (Starr et al., 2003).”
• CD4+T Cells: Differentiation and Functions (2012, background): “A vast repertoire of TCR αβ is generated by gene rearrangement between exons of the variable domains of the V-J segments of α chain and V-D-J segments of β chain [6].”
• Homeostasis of naive and memory T cells. (2008, background): “Introduction The combined processes of positive and negative selection in the thymus allow a tiny fraction of immature thymocytes with low affinity for self-peptide+MHC (pMHC) ligands to survive and differentiate into mature T cells (Starr et al., 2003).”
• NFAT proteins: key regulators of T-cell development and function (2005, background): “Mature T cells that express either CD4 or CD8 are then released into the peripher”
• Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1 (2006, background): “The differentiation of NK cells might have been impaired in Ncr1 gfp/gfp mice, as activating signals are essential for the maturation of the closely related T cell linag”
• TGF-beta: a master of all T cell trades. (2008, positive): “T cells bearing TCRs with low affinity for MHC–self-antigen complexes are favored in this thymic selection, whereas T cells expressing TCRs with high affinity for MHC–self-antigen are eliminated through apoptosis (Starr et al., 2003).”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…cell receptor α www.nursa.org NRS | 2009 | Vol. 7 | DOI: 10.1621/nrs.07003 | Page 9 of 32 (TCRα) gene rearrangement, DP cells expressing TCRαβ receptor undergo a careful selection process to eliminate thymocytes expressing nonfunctional or autoreactive TCR [Starr et al., 2003; Zhang et al., 2005].”