The Hippo pathway: regulators and regulations.

By Fa-Xing Yu, K. Guan. Genes & Development, 2013

1,227 citations recorded by the source corpus.

Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation. Recently, numerous upstream components involved in the Hippo pathway have been identified, such as cell polarity, mechanotransduction, and G-protein-coupled receptor (GPCR) signaling. Actin cytoskeleton or cellular tension appears to be the master mediator that integrates and transmits upstream signals to the core Hippo signaling cascade. Here, we review regulatory mechanisms of the Hippo pathway and discuss potential implications involved in different physiological and pathological conditions.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/5554e3728c97a09f192ac9799c11515fdae38f5b

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In Cell Biology

1. K. Guan
2. Fa-Xing Yu
3. S. Piccolo
4. Z. Meng
5. M. Cordenonsi
6. S. Dupont
7. Toshiro Moroishi
8. Young Chul Kim

Citations in the corpus

• Metabolic control of YAP and TAZ by the mevalonate pathway (2014, background): “have specific extracellular molecules and receptors (Yu and Guan, 2013).”
• Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “The Hippo-YAP/TAZ pathway has emerged as a hub that integrates diverse stimuli including mechanical and cytoskeletal cues, cell adhesion, apico-basolateral polarity, and mitogens to control cell growth and organ size (Pan, 2010; Yu and Guan, 2013).”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “The mammalian orthologs of Hpo, Sav, Wts, Mats, and Yki are Mammalian sterile 20-like 1/2 (MST1/2, also called STK4/3), Salvador (SAV1), Large tumor suppressor homolog 1/2 (LATS1/2), MOB kinase activator 1A/B (MOB1a/b), and Yes-associated protein (YAP)/transcriptional co-activator with PDZ binding m”
• The Hippo signalling pathway and its implications in human health and diseases (2022, background): “29 Generally, there are two types of cell polarity: apicobasal polarity (AP) and planar cell polarity (PCP).”