Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

By Andrew M. Handorf, Yaxian Zhou, M. Halanski, Wan-Ju Li. Organogenesis, 2015

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Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “…factors and ECMproteins play significant roles in the development of fibrotic diseases in many tissues including liver, lung and kidney (Wynn and Ramalingam, 2012; Bonnans et al., 2014; Handorf et al., 2015), requiring genuine culture models that can mimic in vivo conditions for such diseases.”
Cellular Mechanotransduction: From Tension to Function (2018, background): “Depending on the function in the body, softer tissues such as brain (1 kPa) and harder tissues such as bone (1 GPa) can be identified (Handorf et al., 2015).”