Linking actin dynamics and gene transcription to drive cellular motile functions
By E. Olson, Alfred Nordheim. Nature reviews. Molecular cell biology, 2010
973 citations recorded by the source corpus.
Numerous physiological and pathological stimuli promote the rearrangement of the actin cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively obvious that cell motility requires coordinated protein biosynthesis, until recently the linkage between cytoskeletal actin dynamics and correlated gene activities remained unknown. This knowledge gap was filled in part by the discovery that globular actin polymerization liberates myocardin-related transcription factor (MRTF) cofactors, thereby inducing the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics. This insight stimulated research to better understand the actin–MRTF–SRF circuit and to identify alternative mechanisms that link cytoskeletal dynamics and genome activity.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cc1d009c5e5079d2082b0473c71808f9c8be3036
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Citations in the corpus
- Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation (2013, background): “Widely expressed transcriptional regulators that include YAP1 of the Hippo pathway, which promotes growth and regeneration (17), as well as components of the serum response factor (SRF) pathway, which promote cytoskeletal gene expression in differentiation (18), exhibit low nuclear activity in cells”
- Actin Structure and Function (2011, positive): “MAL shuttles between the cytoplasm and the nucleus, where it regulates the activity of the transcription factor serum response factor (SRF).”
- Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “) and gene-expression pathways that operate over hours or days (such as the induction of vinculin through serum response facto”