Shaping cups into phagosomes and macropinosomes

By J. Swanson. Nature reviews. Molecular cell biology, 2008

937 citations recorded by the source corpus.

The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis requires the formation of large endocytic vacuolar compartments inside cells by the organized movements of membranes and the actin cytoskeleton. Fc-receptor-mediated phagocytosis is guided by the zipper-like progression of local, receptor-initiated responses that conform to particle geometry. By contrast, macropinosomes and some phagosomes form with little or no guidance from receptors. The common organizing structure is a cup-shaped invagination of the plasma membrane that becomes the phagosome or macropinosome. Recent studies, focusing on the physical properties of forming cups, indicate that a feedback mechanism regulates the signal transduction of phagocytosis and macropinocytosis.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b2ee4a70a71fda1a7d2ef632a3d12caa0c86b48e

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Citations in the corpus

• Pathways and mechanisms of endocytic recycling (2009, neutral): “There are also specialized actin-driven CIE pathway”
• Routes and mechanisms of extracellular vesicle uptake (2014, background): “Phagocytosis is a receptor-mediated event that involves the progressive formation of invaginations surrounding the material destined for internalization, with or without the participation of enveloping membrane extensions (as required for macropinocytosis) (78,107).”
• Phagocytosis: An Immunobiologic Process. (2016, background): “Attachment of a particle to a macrophage plasma membrane is necessary but not sufficient for its engulfment (Swanson, 2008).”
• Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “For particle phagocytosis (the active engulfment of particulates by professional phagocytes, including macrophages and dendritic cell”
• Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling (2010, background): “Activated Rac1/Cdc42 stimulate WASP and SCAR/ WAVE, which induce actin polymerization via the Arp2/3 complex (Ridley, 2006; Swanson, 2008).”
• Physical Principles of Nanoparticle Cellular Endocytosis. (2015, background): “The membrane ruffles exhibit different shapes, and when close, form large organelles called macropinosomes.(19) Because of the micrometer length scale of phagocytosis and macropinocytosis, actin assembly plays an imperative role in the uptake process.”
• Cytotoxicity and genotoxicity of silver nanoparticles in human cells. (2009, background): “There are different types of active endocytic pathways such as receptor mediated endocytosis (clathrin or caveoli mediated) and macropinocytosis.(51) A detailed study will be conducted to unravel the mechanism involved in Ag-np uptake.”
• Virus Entry by Endocytosis (2013, neutral): “First, they can lead to cell-to-cell infection that allows very rapid and synchronized replication of virus compared to the cell-free infection [25, 26].”