Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

By K. Parmar, P. Mauch, J. Vergilio, R. Sackstein, J. Down. Proceedings of the National Academy of Sciences of the United States of America, 2007

901 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/988af722041b203c14c5f9004aae2ab016834293

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. G. Semenza
2. M. C. Simon
3. Jeremy N. Rich
4. Ralph J. Deberardinis
5. B. Keith
6. Richard J. Johnson
7. Amato J. Giaccia
8. Erinn B. Rankin

In Genetics

1. G. Semenza
2. Jeremy N. Rich
3. M. C. Simon
4. Amato J. Giaccia
5. Richard J. Johnson
6. Erinn B. Rankin
7. Ralph J. Deberardinis
8. B. Keith

In Hematology

1. G. Semenza
2. S. Morrison
3. T. Suda
4. K. Takubo

Citations in the corpus

• Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013, background): “Adult LT-HSCs are maintained in a hypoxic state in the bone marrow (BM) niche (Parmar et al., 2007; Takubo et al., 2010).”
• A Specialized Vascular Niche for Adult Neural Stem Cells (2008, background): “Relatively quiescent stem cells have been proposed to be maintained in hypoxic regions in other stem cell niches such as the bone marrow (Parmar et al., 2007).”
• Hypoxia-inducible factors in stem cells and cancer (2009, positive): “Several lines of study have indicated a potential involvement of low O2 in the maintenance of cell quiescence [41], proliferation [13] and differentiation [14, 16].”
• The role of oxygen availability in embryonic development and stem cell function (2008, background): “It has been proposed that HSCs and their proliferating progenitors are naturally distributed along this gradient, with the HSCs occupying the most hypoxic niche”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “Parmar et al. (2007) administered a perfusion tracer into mice and found that HSCs were relatively enriched in a low-perfusion cellular compartment in the BM.”
• Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, positive): “The regulation of the bone marrow niche is an area of active investigation, but it is notable that the bone marrow is maintained at a relatively low oxygen tension relative to the systemic circulation (Parmar et al., 2007).”
• The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche (2010, background): “Cell Li and Li, 2006; Parmar et al., 2007), these characteristics have not been exploited for identification of unique metabolic properties of HSCs, or for HSC enrichment.”