Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning

By Ian R. Henderson, Xiaoyu Zhang, Cheng Lu, L. Johnson, Blake C. Meyers, Pamela J. Green, Steven E. Jacobsen. Nature Genetics, 2006

638 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/97f96b2233e6263914771c6ba6d09ef85f3ac371

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

Citations in the corpus

ShortStack: comprehensive annotation and quantification of small RNA genes. (2013, background): “A list of 25 Arabidopsis small RNA loci previously annotated as producing phased siRNAs was curated from the literature (Howell et al. 2007; Chen et al. 2010).”
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome (2013, positive): “We tested 29 mutants previously suggested to affect RdDM (Gu et al., 2011; He et al., 2009; Henderson et al., 2006; Law and Jacobsen, 2010; Zheng et al., 2009).”
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. (2006, methodology): “Just as DCL1, which is primarily responsible for miRNA biogenesis, can generate some siRNAs (Borsani et al. 2005; Bouche et al. 2006; Henderson et al. 2006), DCL4, which is primarily responsible for siRNA biogenesis, can generate some miRNAs.”
Applications of next-generation sequencing technologies in functional genomics. (2008, background): “thaliana [74–80]; wheat, Triticum aestivum [81]; the basal eudicot species Eschscholzia californica [82]; the lycopod Selaginella moellendorffii [74]; the unicellular alga Chlamydomonas rein-”
High-Throughput Sequencing of Arabidopsis microRNAs: Evidence for Frequent Birth and Death of MIRNA Genes (2007, background): “In fact, the genomes of Arabidopsis and other plants contain a wide diversity of non-conserved, local inverted duplications that yield small RNA populations ranging from highly uniform, DCL1-dependent miRNAs (e.g. MIR163) to heterogeneous collections of bidirectional short interfering RNAs (siRNAs) ”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “thaliana indicated that RNA-directed DNA methylation of the FWA transgene requires Dicer (DCL3) and Argonaute (AGO4), and is linked to histone H3 lysine 9 (H3K9) methylation, indicating that RNA-directed DNA methylation and RNAi have common molecular mediator”
Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends (2008, background): “2 online) against small RNAs sequenced from inflorescences of Arabidopsis ecotype Col-0 and the rdr2 and dcl2 , 3,4 triple mutants (enriched for miRNAs and reduced in small interfering (siRNAs”
Epigenetic inheritance in plants (2007, background): “Plants encode multiple homologues of the RNAi-machinery components, some of which are specialized for function in RNA-directed DNA methylatio”
Specialization and evolution of endogenous small RNA pathways (2007, background): “Arabidopsis thaliana DCL2, DCL3 and DCL4 collectively have a limited capacity to process imperfect foldbacks from miRNA loc”
Genome-wide high-resolution mapping and functional analysis of DNA methylation in arabidopsis. (2006, background): “Furthermore, DNA methylation persisted in the dcl2 dcl3 dcl4 triple mutant that lacks detectable tasiRNAs (Henderson et al., 2006).”
Small RNA sorting: matchmaking for Argonautes (2010, background): “As plants lack a Drosha orthologue, pri-miRNAs are converted into mature miR:miR* duplexes by a single RNase III family enzyme, DICER-LIKE 1 (DCL1”