Mucins in cancer: function, prognosis and therapy

By D. Kufe. Nature Reviews. Cancer, 2009

1,379 citations recorded by the source corpus.

Epithelia are protected from adverse conditions by a mucous barrier. The secreted and transmembrane mucins that constitute the mucous barrier are largely unrecognized as effectors of carcinogenesis. However, both types of mucins are intimately involved in inflammation and cancer. Moreover, diverse human malignancies overexpress transmembrane mucins to exploit their role in signalling cell growth and survival. Mucins have thus been identified as markers of adverse prognosis and as attractive therapeutic targets. Notably, the findings that certain transmembrane mucins induce transformation and promote tumour progression have provided the experimental basis for demonstrating that inhibitors of their function are effective as anti-tumour agents in preclinical models.

Subfields: Immunology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/ff5a34f6ce1d6df8a9596b05f45bc0d9b7ea6895

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Hanes
2. L. Ensign
3. P. Mukherjee
4. S. Nath
5. M. Esteban

In Molecular Biology

1. L. Ensign
2. J. Hanes
3. P. Mukherjee
4. S. Nath
5. M. Esteban

In Plant Science

1. P. Mukherjee
2. S. Nath

Citations in the corpus

• Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals (2019, neutral): “5–40 MDa) made of monomers connected through disulfide bonding, and these macromolecules are subsequently crosslinked to build up the mucosal layer [82,83].”
• Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment (2019, background): “Interestingly, over-expression of mucins, MUC-1 in particular, have been detected in many human malignancies and seem to promote cancer cell growth and survival (17).”
• MUC1: a multifaceted oncoprotein with a key role in cancer progression. (2014, background): “The sugar chains oligomerize to form a mucinous gel that lubricates and protects the underlying epithelia from desiccation, changes in pH, pollutants, and microbes [8].”
• Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers (2011, background): “There is also extensive evidence that cell-bound mucins play a significant role in the progression of epithelial cancers; cancer cells overexpress transmembrane mucins that promote cell growth and survival [126].”