From cells to organs: building polarized tissue

By David M. Bryant, Keith E. Mostov. Nature reviews. Molecular cell biology, 2008

807 citations recorded by the source corpus.

How do animal cells assemble into tissues and organs? A diverse array of tissue structures and shapes can be formed by organizing groups of cells into different polarized arrangements and by coordinating their polarity in space and time. Conserved design principles underlying this diversity are emerging from studies of model organisms and tissues. We discuss how conserved polarity complexes, signalling networks, transcription factors, membrane-trafficking pathways, mechanisms for forming lumens in tubes and other hollow structures, and transitions between different types of polarity, such as between epithelial and mesenchymal cells, are used in similar and iterative manners to build all tissues.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/db3847e0d86761da8a70db142090e1dab20727e1

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Citations in the corpus

MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “jpg"/> Throughout embryogenesis, cells bud off from developing tissues and move outwards to shape and pattern the complex architecture of prospective organ”
Nanotechnological strategies for engineering complex tissues (2010, background): “Cells that do not contact the ECM or ones lacking apical surfaces will undergo apoptosis or generate a lumen at a region of contact with other cell”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “How cells maintain this polarity has been the subject of intense research as newly synthesized molecules traffic to their proper destination, and to do so, they must use molecular codes for apical and basolateral targeting (194, 1030, 1696).”
A molecular network for de novo generation of the apical surface and lumen (2010, background): “Polarization requires the interaction of the signalling complexes and scaffolds that define cortical domains with membrane-sorting machiner”