The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

By S. Gasser, S. Orsulic, E. Brown, D. Raulet. Nature, 2005

1,404 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/97183e29a55f64fd86762327ae2e389fa36bf34f

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Citations in the corpus

NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “Early surveillance would be in accord with published evidence that NKG2D ligands are induced by the DNA-damage response (Gasser et al., 2005), which is known to be activated at an early stage in tumorigenesis (Bartkova et al., 2005; Gorgoulis et al., 2005).”
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. (2009, positive): “There are well-established data that tumors can be recognized by NK cells via ligands that mark ‘‘stressed self’’ (Gasser et al., 2005).”
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. (2013, neutral): “The SASP might alert nearby cells to potential danger and promote immune clearance of the damaged cells (67, 68, 89).”
Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “NKG2D ligands can be induced by genotoxic stress and stalled DNA replication, conditions that activate DNA damage checkpoint pathways (73).”
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “In addition to inducing cytokines, DNA damage also enhances the expression of ligands of natural killer (NK) cells such as NKG2D ligands (Gasser et al., 2005; Lam et al., 2014).”
NK cells and cancer immunosurveillance (2008, background): “The DNA damage response involves activation of protein kinases ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3related) kinases which are sensors of DNA doublestrand breaks and stalled DNA replication, respectively (Gasser et al., 2005).”
Senescence of activated stellate cells limits liver fibrosis (2008, background): “Of note, Rae family proteins, the NKG2D ligands in mice, are upregulated in response to DNA damage (Gasser et al., 2005), which also is a trigger for cellular senescence (Bartkova et al.”
Aging, Cellular Senescence, and Cancer (2012, background): “In addition, genomic damage—a common cause of cellular senescence—induces expression of the membranebound ligands for the major natural killer cell receptor NKG2D (140).”
Combining radiotherapy and cancer immunotherapy: a paradigm shift. (2013, background): “Although radiation can promote homing and extravasation of effector T cells at the tumor site and induce the expression of molecules that enhance the recognition of the tumor by T cells (30,32,37,40,42,48), these steps are generally insufficient, thus explaining, in part, the rarity of abscopal effe”
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer (2013, background): “activating receptor, resulting in augmented NK-cell cytotoxicity and IFN-g production.(113) Numerous agents promote functional downregulation of the inhibitory NK ligand Clr-b”
New insights into cancer immunoediting and its three component phases — elimination, equilibrium and escape (2014, positive): “NKG2D ligands can be induced on tumour cells by a variety of other stimuli, including Ras signaling and the DNA damage response [23,24].”
Why do viruses cause cancer? Highlights of the first century of human tumour virology (2010, background): “3a ) with roles traditionally ascribed to preventing tumour cell formation might also play a part in immunity to viral infectio”
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, neutral): “Proc Natl Acad Sci U S A (2009) 106(49):20847–52.”