The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

By Tuo Li, Zhijian J. Chen. Journal of Experimental Medicine, 2018

1,128 citations recorded by the source corpus.

The cGAS–cGAMP–STING pathway mediates immune and inflammatory responses to cytosolic DNA. This review summarizes recent findings on how genomic instability leads to cGAS activation and how this pathway critically connects DNA damage to autoinflammatory diseases, cellular senescence, and cancer.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/5da20bf7e416fb48e69a8eedf0986b87e6e9da55

How researchers see this paper

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In Immunology

1. J. Campisi
2. M. Demaria
3. Manuel Serrano
4. V. Krizhanovsky
5. P. Jat
6. R. Kumari
7. M. Collado
8. Guido Kroemer

In Infectious Diseases

1. Guido Kroemer
2. P. Jat
3. R. Kumari

Citations in the corpus

• Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “…and transposable elements can stimulate cyclic GMP– AMP synthase linked to stimulator of interferon genes (cGASSTING) pathway and regulate SASP both in vitro and in vivo where senescence was induced by different stimuli (Dou et al., 2017; Glück et al., 2017; Yang et al., 2017; Li and Chen, 2018).”
• Ferroptosis in infection, inflammation, and immunity (2021, background): “In addition, STING1 induces the activation of autophagy (Gui et al., 2019) or immunocoagulation (Zhang et al., 2020) through a mechanism independent of TBK1-IRF3 signaling.”
• Cellular Senescence: Defining a Path Forward. (2019, background): “The normally repressed LINE-1 (L1) retrotransposons are activated, stimulating the cGAS-STING pathway that elicits a type 1 interferon response (see Secretion) (De Cecco et al., 2013).”