Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer

By L. Bracci, G. Schiavoni, A. Sistigu, F. Belardelli. Cell Death and Differentiation, 2013

873 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Regulatory mechanisms of PD-1/PD-L1 in cancers (2024, background): “Preclinical studies have shown that chemotherapy promotes the infiltration of T cells into tumor tissues and decreases the number of immunosuppressive cells, thus enhancing the sensitivity of tumor cells to immune checkpoint blockade therapy [420].”
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “…even if chemotherapy caused massive lymphodepletion, this could ultimately reset the immune system by favoring the rebound replenishment of various immune cell subsets (Bracci et al., 2014), and/or allow the emergence of a specific effector cell type with anticancer activity (Romero et al., 2014).”