Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.

By R. R. Pandey, T. Mondal, Faizaan Mohammad, Stefan Enroth, Lisa Redrup, J. Komorowski, Takashi Nagano, Debora Mancini-DiNardo, C. Kanduri. Molecules and Cells, 2008

1,233 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9666748b86f964b38be28188adfebd0feaf5f901

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Citations in the corpus

Genome regulation by long noncoding RNAs (2012, background): “Both Air and Kcnq1ot1 are lncRNAs that are transcribed from the silenced paternal allele, and specifically bind to and recruit the histone H3 lysine 9 methylase G9a in cis to mediate H3K9me3 and transcriptional silencing of Kcnq1 or Igf2r loci, respectively (87, 88).”
Control of Embryonic Stem Cell State (2011, background): “…complexes to the X-inactivation center X(ic), the kcnq1 domain, the INK4b/ARF/INK4a locus, the HOXD locus, andmany other genomic loci in ESCs and other cell types (Gupta et al., 2010; Pandey et al., 2008; Rinn et al., 2007; Tsai et al., 2010; Yap et al., 2010; Zhao et al., 2010; Zhao et al., 2008).”
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis. (2012, background): “…lncRNAs have been shown to interact with and modulate the activity of the chromatin modifying machinery (Rinn et al. 2007; Nagano et al. 2008; Pandey et al. 2008; Zhao et al. 2008, 2010; Khalil et al. 2009; Huarte et al. 2010; Tian et al. 2010; Tsai et al. 2010; Guttman et al. 2011; Wang et…”
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “The ‘‘guiding’’ lncRNAs, like KCNQ1OT1 (Pandey et al., 2008) and lincRNA-p21 (Huarte et al.”
Regulatory roles of natural antisense transcripts (2009, background): “Instead, antisense transcripts accumulate locally and trigger DNA or chromatin modification”
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, background): “Prior work has also shown that long, non-coding RNAs such as Xist, Kcnq1ot1 and HOTAIR can repress genes in cis- or trans- through interaction with PcG complexes [37–40].”
Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, neutral): “, 2007) and Kcnq1ot1 (Pandey et al., 2008) is correlated with target silencing.”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “Similarly, the long ncRNA KCNQ1OT1 can mediate PRC2 spreading in cis , thereby maintaining the imprinted expression of the KCNQ1 domai”
Chromatin Structure and the Inheritance of Epigenetic Information (2010, background): “This phenomenon may be important in gene imprintin”
Long noncoding RNA in prostate, bladder, and kidney cancer. (2014, background): “Loss of maternal-specific methylation is the most frequent defect in BWS, resulting in activation of KCNQ1OT1 and silencing of the negative regulator of cell proliferation and tumour suppressor cyclin-dependent kinase inhibitor 1C (CDKN1C, p57, Kip2) [40,41].”
X-inactivation, imprinting, and long noncoding RNAs in health and disease. (2013, background): “Many imprinted lncRNAs, such as Gtl2 and Nespas, appear to form a complex with Polycomb proteins (Pandey et al., 2008; Zhao et al., 2010).”