Chromatin Structure and the Inheritance of Epigenetic Information

By R. Margueron, D. Reinberg. Nature reviews genetics, 2010

756 citations recorded by the source corpus.

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying the epigenetic program, it is still unclear how a defined chromatin domain is reproduced following DNA replication and transmitted from one cell generation to the next. Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells. We consider models of how histones might be recycled following replication, and discuss the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/621623812e722080a20292fdf4e7729245d6ab97

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In Molecular Biology

1. D. Reinberg
2. P. Voigt
3. Wee-Wei Tee
4. Bradley E. Bernstein
5. R. Margueron
6. Amir Goren
7. Anja Groth
8. C. Alabert

Citations in the corpus

• Charting histone modifications and the functional organization of mammalian genomes (2011, background): “Specific chromatin configurations may be dictated by DNA sequence, DNA methylation patterns, transcription factors and other regulatory proteins, and transcriptional activity, and may be maintained through epigenetic controls that are rooted in the chromatin machiner”
• Epigenetic plasticity and the hallmarks of cancer (2017, background): “In embryonic stem (ES) cells, hyperdynamic nucleosome exchange hinders the establishment of repressive structures, leavingmanydevelopmental TF genes in a “bivalent” state with “active” and “repressive” histonemarks that “poise” these genes for alternate fates (1, 15, 26).”
• A double take on bivalent promoters. (2013, background): “Moreover, several histone modifications have been implicated as carriers of epigenetic information that can be transmitted through cell division, instructing gene expression patterns in the daughter cells (Probst et al. 2009; Margueron and Reinberg 2010).”
• Child health, developmental plasticity, and epigenetic programming. (2011, background): “Chromatin is generally compartmentalized into two main domain types: heterochromatin, which is condensed and gene-poor, and euchromatin, which is decondensed and gene-rich (72).”
• The Polycomb Complex PRC2 and its Mark in Life (2011, background): “To understand how PRC2 can maintain specific gene-expression patterns, the overall chromatin structure, in addition to H3K27me3 patterns, should be considere”
• Chromatin replication and epigenome maintenance (2012, background): “Mechanisms that maintain chromatin states during the cell cycle are thus germane to cell fate and identit”