Regulatory roles of natural antisense transcripts

By M. Faghihi, Claes Wahlestedt. Nature reviews. Molecular cell biology, 2009

730 citations recorded by the source corpus.

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7bf4cf02a2ca0359bf9ce3341b1c9c9ea9daf0fa

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Citations in the corpus

• Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth (2014, background): “as intragenic natural antisense transcripts (NATs) that are transcribed in the opposite direction to a particular gene.(5,6)”
• Long Noncoding RNAs: Past, Present, and Future (2013, background): “One way to find order in the plethora of reported lncRNAs is to classify them according to genomic location—i.e., from where in the genome these RNAs are transcribed, relative to well-established markers such as protein-coding genes (Figure 1).”
• UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (2009, background): “Additionally, some UTRs may be targeted by complementary natural antisense transcripts masking RNA binding protein or miRNA binding sites (4).”
• RNA sequencing: advances, challenges and opportunities (2010, background): “Strand-specific RNA-seq Transcriptomic studies in a range of species have revealed a pervasive presence of antisense transcription event”
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “TI is defined as [1544, 1545, 1546, 1547, 1548] the “suppressive influence of one transcriptional process, directly and in cis on a second transcriptional process”.”