Pyruvate kinase type M2 and its role in tumor growth and spreading.

By S. Mazurek, C. Boschek, F. Hugo, E. Eigenbrodt. Seminars in Cancer Biology, 2005

831 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/95153ea5c8146b673c7788e625dbf740f0ed63ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. V. Vander Heiden
2. C. V. Dang
3. Sophia Y. Lunt
4. Craig B. Thompson
5. Ralph J. Deberardinis
6. Peng Huang
7. Guido Kroemer
8. David M. Sabatini

In Cancer Research

1. C. V. Dang
2. M. V. Vander Heiden
3. Ralph J. Deberardinis
4. Craig B. Thompson
5. Sophia Y. Lunt
6. David M. Sabatini
7. G. Semenza
8. Guido Kroemer

In Molecular Biology

1. C. V. Dang
2. Ralph J. Deberardinis
3. M. V. Vander Heiden
4. David M. Sabatini
5. Craig B. Thompson
6. Guido Kroemer
7. J. Cantor
8. Sophia Y. Lunt

Citations in the corpus

• Tumor cell metabolism: cancer's Achilles' heel. (2008, background): “Interestingly, this isoform, PKM2, oscillates from high (tetrameric) to low (dimeric) activity (Christofk et al., 2008a; Mazurek et al., 2005).”
• Complexity of dopamine metabolism (2013, background): “Different examples nicely demonstrate the adaptation of cellular metabolism as an result of genetic reorganization and the impact of metabolism on cellular and systemic functionality [10,11].”
• Glycolysis inhibition for anticancer treatment (2006, background): “Interestingly, tumor cells in particular express the PK isoenzyme type M2 (M2-PK), which seem to regulate the proportions of glucose carbons for synthetic processes or for glycolytic energy production (Mazurek et al., 2005).”
• PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis (2012, neutral): “In human cancer cells, PKM2 expression is upregulated (Dombrauckas et al., 2005; Mazurek, 2007; Mazurek et al., 2005).”
• The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “Stable isotope resolved metabolomics (SIRM), indicates enhanced PPP activity in the human breast cancer cell line MCF7 when compared to non-transformed mammary epithelial cells (Meadows et al., 2008).”
• Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages (2015, positive): “Numerous studies have reported a key role for PKM2 in aerobic glycolysis of tumors (Christofk et al., 2008; Mazurek et al., 2005; Tamada et al., 2012).”
• Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer (2009, background): “This form of rapid glutamine utilization and secretion of glutamine by-products, similar to the Warburg effect in its apparent inefficiency, has been proposed to be an additional hallmark of tumor cell metabolism (Mazurek et al., 2005).”
• Regulation of cancer cell metabolism (2011, background): “PK catalyses the rate-limiting, ATP-generating step of glycolysis in which phosphoenolpyruvate (PEP) is converted to pyruvat”
• Cancer cell metabolism: Warburg and beyond. (2008, background): “Surprisingly, the M2-PK of cancer cells is thought to be less active in the conversion of PEP to pyruvate and thus less efficient at ATP production (reviewed in Mazurek et al., 2005).”
• Brick by brick: metabolism and tumor cell growth. (2008, background): “Current Opinion in Genetics & Development 2008, 18:54–61 process [15] (Figure 2b).”
• Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer (2013, positive): “The activity of PKM2 oscillates between the activated tetrameric form and inactivated monomeric state, which constitutes the metabolic budget system in tumor metabolism (Mazurek et al., 2005).”
• Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth (2011, positive): “PKM2, but not PKM1, has a low activity that can be activated allosterically by FBP (Jurica et al., 1998; Mazurek et al., 2005).”
• Pyruvate Kinase M2 Regulates Gene Transcription by Acting as A Protein Kinase (2012, positive): “In tumor cells, PKM2 forms a dimer, and appears to be catalytically inactive for conversion of PEP to pyruvate (Ashizawa et al., 1991; Mazurek et al., 2005).”
• Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “Additionally, cancer cells utilize the less active M2 splice isoform of pyruvate kinase, which catalyzes the step in glycolysis responsible for net ATP synthesis (Mazurek et al 2005).”