Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.

By Sophia Y. Lunt, M. V. Vander Heiden. Annual Review of Cell and Developmental Biology, 2011

2,906 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/006c609f2389cabf7130e452dc0667bfd09fe064

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Citations in the corpus

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “Glycolytic breakdown of glucose produces various intermediate metabolites, which as precursors can be diverted into anabolic pathways including the pentose phosphate pathway (PPP), serine and triacylglycerol synthesis pathways for the de novo synthesis of nucleotides, amino acids, and lipids [10].”
Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “Note that this is considerably less than the >20% estimated for Escherichia coli (52).”
Tumor glycolysis as a target for cancer therapy: progress and prospects (2013, background): “resulting from glycolysis confers a selective growth advantage to cancer cells [30,31].”
Fundamentals of cancer metabolism (2016, background): “intermediates to supply subsidiary pathways to fulfill the metabolic demands of proliferating cells (11).”
Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “Tumors also exhibit variable uptake of glutamine and other metabolites such as 18F-labeled amino acid analogues, and display differential levels of lactate secretion (16, 24, 73, 74).”
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “It is suggested that although efficiency in ATP production per molecule of glucose is much lower via glycolysis, the yield rate is much faster than that in the oxidative phosphorylation [4] and, hence, it meets”
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “NAD is reduced to NADH coupled with the oxidation of G3P to 1,3-BP by GAPDH.(210) Cytosolic pyruvate can also be converted to lactate by LDH, coupled with the oxidation of NADH to NAD.”
NRF2, a Transcription Factor for Stress Response and Beyond (2020, background): “Glutamine, the most abundant amino acid in human plasma and the obligatory nitrogen donor for the biosynthesis of nucleotides and nonessential amino acids, is a major contributor together with glucose to anaplerotic flux [86].”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Simple empirical calculations indicate that the amount of ATP required for cell growth and division may be less than that required for normal cellular maintenance [18,25].”
KRAS: feeding pancreatic cancer proliferation (2014, neutral): “Although an explanation of the advantages of increased glycolysis in cancer cells remains controversial [24], a prevalent hypothesis is that while inefficient in terms of net ATP production, aerobic glycolysis supplies rapidly proliferating cells with high levels of glycolytic intermediates that can”