Tolerance, not immunity, crucially depends on IL-2

By T. Malek, A. Bayer. Nature reviews. Immunology, 2004

894 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9457826bb4ccc10deb25a08c109003f5b8f8da69

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In Immunology

Citations in the corpus

Regulatory T cells in cancer. (2006, background): “Recent work has demonstrated that IL2 signaling is required for thymic development, peripheral expansion and suppressive activity of Treg cells.(93) During immune reconstitution after chemotherapy IL2 therapy led to a homeostatic peripheral expansion of Treg cells and to a markedly increased Treg ce”
Regulatory T cells and immune tolerance. (2008, background): “Instead, these mice spontaneously develop T cell-mediated fatal lymphoproliferative/ inflammatory disease with autoimmune components (such as hemolytic anemia and lymphocytic infiltration into multiple organs) and hyperreactivity to commensal microbes (reviewed in Malek and Bayer, 2004).”
A function for interleukin 2 in Foxp3-expressing regulatory T cells (2005, background): “IL-2 has been linked to the biology of regulatory T cells (T reg cells”
Mechanisms of suppression by suppressor T cells (2005, background): “In fact, IL-2- and IL-2R-deficient mice are also deficient in CD4 + CD25 + suppressor T cells in secondary lymphoid organs, as IL-2 represents an essential factor required to maintain the number and functional integrity of CD4 + CD25 + suppressor T cell”
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection (2009, background): “Over the past few years, a strong body of literature suggests that a primary function of IL-2 is to promote the expansion and survival of Treg cells (Malek and Bayer, 2004).”
IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “This effect is principally due to the generation and maintenance of Treg cells rather than an alteration of central tolerance or an acceleration of activation-induced cell death (24, 25).”
Perioperative Clinical Interventions That Modify the Immune Response in Cancer Patients (2013, background): “For instance, IL-2, the prototypical Th1 cytokine, has shown anticancer activity by augmenting cytolytic activity of NK cells, by inducing IFN-γ, and by activating macrophages [4].”
NetPath: a public resource of curated signal transduction pathways (2010, background): “More recently, IL2 was shown to promote tolerance through its effects on regulatory T cell development [34].”