A function for interleukin 2 in Foxp3-expressing regulatory T cells
By J. Fontenot, J. P. Rasmussen, M. Gavin, Alexander Y. Rudensky. Nature Immunology, 2005
1,952 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/452db1fbe2806d1c2f4a94e7e45b386cb285c68b
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In Immunology
- Alexander Y. Rudensky
- Shimon Sakaguchi
- T. Malek
- Steven Z. Josefowicz
- E. Shevach
- Li-Fan Lu
- J. Bluestone
- I. Castro
Citations in the corpus
- IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “the survival and “fitness” of natural Treg cells (26, 36, 37).”
- Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “Conventional T cell development occurs during fetal development, while Treg cell development is delayed until the early neonatal period in mice (Fontenot et al., 2005a).”
- Regulatory T cells and immune tolerance. (2008, background): “In addition, IL-2 is required for sustained expression of Foxp3 and CD25 in natural Tregs and enhances their suppressive function, at least in vitro (Fontenot et al., 2005; Shevach et al., 2006).”
- Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, neutral): “This syndrome was ameliorated by adoptive transfer of wild-type T reg cells, and the T reg cell defect was cell intrinsic rather than being the result of the lack of interleukin 2 (IL-2) production by STIM-deficient T cell”
- Interleukin-35-mediated induction of a novel regulatory T cell population (2010, background): “Naturally occurring, thymus-derived CD4 + T reg cells (nT reg cells) express the lineage-specific transcription factor Foxp3, which is required for their development, homeostasis and functio”
- The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells (2011, background): “T reg cells depend on interleukin 2 (IL-2) for their maintenance and peripheral homeostasis and consequently have high expression of CD25 (the IL-2 receptor α-chain”