Regulatory T cells in cancer.

By Marc Beyer, Joachim L. Schultze. Blood, 2006

1,083 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/73d2589a2870ef636683cba7f1ebf6cd64853c34

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In Immunology

Citations in the corpus

The polarization of immune cells in the tumour environment by TGFβ (2010, background): “Although the precise mechanism (or mechanisms) causing increased numbers of T Reg cells in malignancies is unknown, TGFβ — as well as other tumour-produced chemical mediators working together with this cytokine, such as prostaglandin E 2 and H-ferritin — has been implicated in inducing T Reg cell”
Hallmarks of cancer: the next generation. (2011, neutral): “Both can suppress the actions of cytotoxic lymphocytes (Mougiakakos et al., 2010; Ostrand-Rosenberg and Sinha, 2009).”
Prostate cancer and inflammation: the evidence (2012, background): “In light of their role in immune suppression, Treg have been investigated for a role as suppressors of antitumour immune responses.(84) Infiltrating Treg have been identified in a number of solid tumours, and in some instances the presence of these cells correlates with poor prognostic outcome (revi”
VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer. (2013, methodology): “Other strategies using anti-CD25 or anti-GITR antibodies could modulate Treg numbers or function but would also affect activated effector T cells (25).”
Oxidative Stress in Cancer (2020, background): “In addition, regulatory T (Treg) cells, which are critical for preventing autoimmunity, suppress effective tumor immunity; the presence of intratumoral Treg cells is often associated with poor prognosis (Beyer and Schultze, 2006).”