Cellular mechanisms and physiological consequences of redox-dependent signalling

By Kira M. Holmström, Toren Finkel. Nature reviews. Molecular cell biology, 2014

1,907 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/938b8c8ac32800a8d56224e851aa0c9cb5726af0

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In Immunology

1. A. Dinkova-Kostova
2. D. Bailey
3. Wei-fen Li
4. J. Hayes
5. Ying Wang
6. Robyn Branicky
7. K. Tew
8. M. Conrad

In Molecular Biology

1. A. Dinkova-Kostova
2. J. Hayes
3. F. Ursini
4. Elias S. J. Arnér
5. D. Bailey
6. Ying Wang
7. Robyn Branicky
8. K. Tew

Citations in the corpus

• The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “For instance, H 2 O 2 , due to its long-lived nature and ability to easily pass through cellular membrane, is an important secondarymessenger inmaintaining the cellular homeostasis under different conditions [1].”
• Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling (2017, background): “In addition, other enzymes, including cytochrome P450 monooxygenase, nitric oxide synthase (NOS), xanthine oxidase, cyclooxygenase (COX), and lipoxygenase (LOX), generate ROS through their enzymatic reaction cycles (Bhattacharyya et al. 2014; Holmström and Finkel 2014).”
• ROS-dependent signal transduction (2014, background): “Examples of these cellular processes include growth factor signaling, hypoxic signal transduction, autophagy, immune responses, and stem cell proliferation and differentiation [4].”
• Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, positive): “These include the mitochondrial electron transport chain (ETC), the plasma membrane–associated NAD PH oxidase complex (NOX), the cytosolic xanthine oxidase, and the cytochrome p450 monooxygenases, which are present mainly in the ER (Holmström and Finkel, 2014).”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “In a physiological context, the vast majority of cellular ROS is produced in mitochondria using NADH as electron donor.(114,115) Mitochondrial NADH supplies NADH dehydrogenase (complex I) with electrons, which along with the electrons obtained from FADH2 via complex II drive the mitochondrial ETC to”
• Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “Apart from that, numerous other enzymes such as xanthine oxidase, nitric oxide synthase, cyclooxygenases, cytochrome P450 enzymes, and lipoxygenases as well as other cell organelles, like the peroxisome and endoplasmic reticulum, contribute to intracellular ROS production [6].”
• Antioxidant Properties of Probiotic Bacteria (2017, background): “These cytosolic factors combine with the membrane-bound NOX2 and p22phox to generate the classic phagocyte response to stimulation known as the respiratory burst [97,98].”
• Calcium and ROS: A mutual interplay (2015, background): “ROS at moderate levels represent significant signaling molecules, which are widely involved in physiological processes through oxidizing proteins, lipids and polynucleotides [47,75].”