Calcium and ROS: A mutual interplay
By A. Görlach, K. Bertram, S. Hudecova, O. Krizanova. Redox Biology, 2015
1,408 citations recorded by the source corpus.
Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca2+ signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders.
Subfields: Cell Biology, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/b375646e8a8530f2e89b4e8c09f203474e6ab15c
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Citations in the corpus
- Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…al., 2011; Ray et al., 2012; Nathan and Cunningham-Bussel, 2013; Navarro-Yepes et al., 2014; Reczek and Chandel, 2014; Schieber and Chandel, 2014; Gorlach et al., 2015), this review will focus on ROS generated by innate phagocytes, specifically by polymorphonuclear leukocytes (PMNs) via the…”
- PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “Consequently, the cell’s metabolic state strongly impacts the capacity of ROS production by mitochondria in a PGC-1α-dependent mechanism [77, 78].”
- 13 reasons why the brain is susceptible to oxidative stress (2018, background): “The interested reader is referred elsewhere for a comprehensive review of Ca/ redox interplay [35], our discourse is confined to three points.”