The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

By H. Tan, Ning Wang, Sha Li, M. Hong, Xuanbin Wang, Yibin Feng. Oxidative Medicine and Cellular Longevity, 2016

602 citations recorded by the source corpus.

High heterogeneity of macrophage is associated with its functions in polarization to different functional phenotypes depending on environmental cues. Macrophages remain in balanced state in healthy subject and thus macrophage polarization may be crucial in determining the tissue fate. The two distinct populations, classically M1 and alternatively M2 activated, representing the opposing ends of the full activation spectrum, have been extensively studied for their associations with several disease progressions. Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the reasons of ROS abundance in certain phenotype. M1 macrophages majorly clearing the pathogens and ROS may be crucial for the regulation of M1 phenotype, whereas M2 macrophages resolve inflammation which favours oxidative metabolism. Therefore how ROS play its role in maintaining the homeostatic functions of macrophage and in particular macrophage polarization will be reviewed here. We also review the biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases. The potential therapeutic opportunities targeting ROS will also be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/323f04e90362ae55ffa419b1ed33d3fc94d95c58

How researchers see this paper

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In Immunology

1. L. Galluzzi
2. Guido Kroemer
3. Klaus Ley
4. L. Zitvogel
5. M. Smyth
6. V. Schirrmacher
7. Oliver Kepp

Citations in the corpus

• Mitochondrial metabolism and cancer (2017, background): “However, the oxidative burst that underlies the phagocytic activity of M1 macrophages depends on ROS of direct or indirect (via NADPH) mitochondrial derivation [221].”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “Intriguing accumulated evidence suggests a critical role of ROS in regulating macrophage polarization [145], but the specific contribution of ROS levels controlled by PGC-1α during this process is an exciting question yet to be addressed.”
• Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages (2019, background): “Opposed to the in vivo M1(=LPS+)C57BL/6J activation, in vivo M2(=LPS–)C57BL/6J regulated gene transcription occurs in conditions favoring mitochondrial metabolism and oxidative glucose metabolism, with an increase of anabolic process that properly corresponds with the in vivo M2 functions (94, 95).”