ROS-dependent signal transduction

By Colleen R. Reczek, Navdeep S. Chandel. Current Opinion in Cell Biology, 2014

784 citations recorded by the source corpus.

Reactive oxygen species (ROS) are no longer viewed as just a toxic by-product of mitochondrial respiration, but are now appreciated for their role in regulating a myriad of cellular signaling pathways. H2O2, a type of ROS, is a signaling molecule that confers target specificity through thiol oxidation. Although redox-dependent signaling has been implicated in numerous cellular processes, the mechanism by which the ROS signal is transmitted to its target protein in the face of highly reactive and abundant antioxidants is not fully understood. In this review of redox-signaling biology, we discuss the possible mechanisms for H2O2-dependent signal transduction.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a776ac969abaa2316793b3156e8e24ad7bd47a0b

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In Molecular Biology

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Citations in the corpus

• Reactive Oxygen Species and Antioxidant Defense in Plants under Abiotic Stress: Revisiting the Crucial Role of a Universal Defense Regulator (2020, background): “Therefore, scientists used the term “redox biology” to refer to ROS as signaling molecules to control and uphold the usual physiological activities of plants [11,64,65].”
• Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, neutral): “The redox relay model proposes that thiol peroxidases, in particular Prxs, are the initial recipients of H2O2 and subsequently transfer redox equivalents to the end targets (Reczek and Chandel, 2015; Stöcker et al., 2018).”
• Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Moreover, functional changes derived from redox modifications can affect the transcriptional process, phosphorylation and other events involved in signaling, or can alter the metabolic fluxes by modification of the enzymatic activities (Reczek and Chandel 2015).”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “While various cell types can produce ROS by different machineries to regulate and influence cellular processes (Trachootham et al., 2008; Bae et al., 2011; Ray et al., 2012; Nathan and Cunningham-Bussel, 2013; Navarro-Yepes et al., 2014; Reczek and Chandel, 2014; Schieber and Chandel, 2014; Gorlach ”
• Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases (2018, background): “Once oxidized, glutathione reductase is capable to regenerate glutathione from glutathione disulfide via NADPH-dependent process (Reczek and Chandel, 2015).”
• Role of Glutathione in Cancer: From Mechanisms to Therapies (2020, background): “All of these can modify the structure and activity of proteins [11].”
• Store-Operated Calcium Channels. (2015, neutral): “Further work will be needed to resolve these contradictory findings; mechanisms of redox modulation are often complex, as they reflect the balance between ROS and antioxidant scavenger levels (317), as well as the potential contributions of additional reactive cysteines located elsewhere in the prot”
• The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview (2021, background): “Numerous authors emphasize the importance of maintaining the basal level of ROS above cytostatic and below cytotoxic, which allows redox reactions and essential processes regulation to happen (Truong and Carroll, 2013; Schieber and Chandel, 2014; Reczek and Chandel, 2015; Diebold and Chandel, 2016; ”