The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

By M. Veldhoen, K. Hirota, A. Westendorf, J. Buer, L. Dumoutier, J. Renauld, Brigitta Stockinger. Nature, 2008

1,688 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/92ec2cfbeebf863350bbbf9d77b3cf1fcb7a5448

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In Immunology

Citations in the corpus

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22 (2011, background): “, a cytosolic transcription factor that recognizes many endogenous metabolites and environmental toxins as activating ligands and seems to be critical for IL-22 production in other cell population”
Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, background): “Interestingly, IL-1induced IL-22 expression in Th17 cells differentiated in the presence of exogenous TGF-b, suggesting the plasticity of IL-22 expression.”
Human nutrition, the gut microbiome, and immune system: envisioning the future (2011, background): “and promotes T H 17-cell and T reg -cell differentiation and effector activit”
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells (2009, background): “AHR has been reported to be another transcriptional regulator of T H -17 cells, as agonists of this receptor increase expression of IL-17 and IL-22 (refs”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “AHR was recently shown in mice to be critical for the differentiation of naive T cells to Th17 versus FoxP3 Treg cells (Quintana et al., 2008; Veldhoen et al., 2008).”
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling (2011, background): “The ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) has a critical role in regulating IL-22 production by mouse T cell”
AN INTERACTION BETWEEN KYNURENINE AND THE ARYL HYDROCARBON RECEPTOR CAN GENERATE REGULATORY T CELLS, (2010, background): “ligand, 6-formylindolo[3,2-b]carbazole (FICZ), leads to Th17 cell formation (19).”
Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010, background): “Th17 cell differentiation is associated with expression of several transcription factors, including RORgt, RORa, RUNX1, BATF, IRF-4, AHR, and c-Maf (Bauquet et al., 2009; Brüstle et al., 2007; Ivanov et al., 2006; Schraml et al., 2009; Veldhoen et al., 2008; Yang et al., 2008b; Zhang et al., 2008).”
Homeostatic immunity and the microbiota (2017, neutral): “Within the gastrointestinal tract, AhR-activation promotes IL-22 production by group 3 innate lymphoid cells (ILC) and Th17 cells (Kiss et al., 2011; Qiu et al., 2012; Veldhoen et al., 2008; Zelante et al., 2013), and the maintenance of intra-epithelial Belkaid and Harrison Page 4”