Human nutrition, the gut microbiome, and immune system: envisioning the future

By A. Kau, Philip P. Ahern, Nicholas W. Griffin, A. Goodman, Jeffrey I. Gordon. Nature, 2011

2,459 citations recorded by the source corpus.

Marked changes in socio-economic status, cultural traditions, population growth and agriculture are affecting diets worldwide. Understanding how our diet and nutritional status influence the composition and dynamic operations of our gut microbial communities, and the innate and adaptive arms of our immune system, represents an area of scientific need, opportunity and challenge. The insights gleaned should help to address several pressing global health problems.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a18d706e33ae59c18156dfedf3a13261ac744ad5

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Citations in the corpus

The Intestinal Microbiome in Early Life: Health and Disease (2014, background): “Nutritional interventions are not sufficient to reverse symptoms of malnutrition in two-thirds of children, suggesting that the microbiota composition in the small intestine may skew the interactions between immunity and metabolism to a scenario where nutrient uptake and microbe-host mutualism are n”
Mining the human gut microbiota for immunomodulatory organisms (2017, neutral): “Themammalian gastrointestinal tract is inhabited by hundreds of species of symbiotic microbes, many of which have a beneficial impact on the host (Kamada et al., 2013; Kau et al., 2011).”
Gut Microbiota and Immune System Interactions (2020, background): “SCFAs are fatty acids with fewer than six carbon atoms, mainly consisting of acetate, propionate, and butyrate [1,9].”
Interaction between the gut microbiome and mucosal immune system (2017, background): “, by the synthesis of vitamins [8] and short chain fatty acids (SCFAs) [9, 10].”
Antioxidant Properties of Probiotic Bacteria (2017, background): “Butyrate is a short-chain fatty acid (SCFA) produced by microbiota in the colon and distal small intestine from resistant starch, dietary fiber, and low-digestible polysaccharides by fermentation [64].”
Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms (2012, background): “dietary fiber, and other low-digestible polysaccharides in a fermentation process [1].”
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. (2012, background): “Intestinal epithelial cells, underlying immune tissues, and the microbiota establish a state of equilibrium that optimizes resistance to infection and facilitates the absorption of nutrients [26].”