Hippo pathway regulation by cell morphology and stress fibers

By K. Wada, K. Itoga, T. Okano, S. Yonemura, H. Sasaki. Development, 2011

866 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/68328733d1189ef418fb9b764daca706c9f48e5a

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Citations in the corpus

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment (2013, background): “F-actin formation in the stress fiber is required for the disruption of Hippo signaling and nuclear YAP accumulation (29).”
The Hippo Signaling Pathway in Development and Disease (2019, background): “Indeed, manipulating cell geometry by other means result in similar changes in YAP activity (Dupont et al., 2011; Wada et al., 2011).”
The Hippo pathway: regulators and regulations. (2013, background): “On the other hand, Lats kinases were required for YAP/TAZ regulation by GPCR signaling, cell attachment, and cell geometry (Wada et al. 2011; Mo et al. 2012; Yu et al. 2012b; Zhao et al. 2012).”
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “In general, RhoGTPase activity and F-actin appear to activate YAP/TAZ, whereas destabilization of F-actin inhibits YAP/TAZ (Dupont et al., 2011; Miller et al., 2012; Wada et al., 2011; Yu et al., 2012; Zhao et al., 2012).”
YAP/TAZ at the roots of cancer (2016, background): “…phosphorylation by LATS an important yet not an absolute determinant of their nuclear localization or stability (Aragona et al., 2013; Barry et al., 2013; Das et al., 2016; Dupont et al., 2011; Rashidian et al., 2015; Ren et al., 2010; Sorrentino et al., 2014; Wada et al., 2011; Wang et al., 2014).”
The Hippo signalling pathway and its implications in human health and diseases (2022, background): “It was shown that YAP accumulates in the nucleus in flat spread cells, while in round compact cells, YAP localizes in the cytoplasm.(90) Liquid flow force represents another upstream mechanical cue that regulates the Hippo pathway.”
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. (2013, neutral): “…proteins appeared as ideal candidates: treatments that disrupt F-actin or cytoskeletal contractility oppose YAP/TAZ function (Dupont et al., 2011; Wada et al., 2011; Zhao et al., 2012); then, it is recognized that cells respond to external mechanical cues by adjusting the tension and overall…”
Forces in tissue morphogenesis and patterning. (2013, neutral): “YAP/TAP nuclear localization is determined by ECM stiffness—high ECM stiffness and cell spreading increase cortical tension and promote stress fiber formation, which, via an yet unknown mechanism, lead to YAP/TAZ translocation to the nucleus, whereas low stiffness and cell rounding promote cytoplasm”
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges (2019, background): “Hippo-YAP pathway was modulated by cell shape and mechanotransduction [160,161].”
The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “1) S127-phosphorylated YAP can be found in the nucleus (217).”
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, neutral): “At the mechanical level, YAP is regulated by mechanical cues such as extracellular matrix (ECM) rigidity, strain, shear stress, or adhesive area (Aragona et al., 2013; Benham-Pyle et al., 2015; Calvo et al., 2013; Chaudhuri et al., 2016; Dupont et al., 2011; Elosegui-Artola et al., 2016; Nakajima et”