The biology of YAP/TAZ: hippo signaling and beyond.
By S. Piccolo, S. Dupont, M. Cordenonsi. Physiological Reviews, 2014
1,670 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7ccee5fa1f4011f36359dd09d8b913904476a7a9
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Citations in the corpus
- Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Meanwhile, when in the nucleus, they readily interact with DNA-binding transcription factors, particularly TEA domain family members (TEAD), to regulate genetic expression associated with proliferation, a key hallmark of cancer [154,155].”
- Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “, 2012, 2014b), as well as crosstalk with Wnt or TGFb signaling (Moroishi et al., 2015; Piccolo et al., 2014).”
- Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Finally, we evaluated YAP localization after overexpressing LATS and MST, both of which promote YAP phosphorylation and, thereby, promote YAP cytoplasmic retention (Piccolo et al., 2014).”
- The Hippo signalling pathway and its implications in human health and diseases (2022, background): “21,148 The Hippo pathway has been shown to restrict the proliferation of cardiomyocytes, 10,149 the molecular mechanism in which involves the Wnt 150 or Pi3kcb-mediated PI3K-AKT 151 signalling pathways.”
- YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration (2018, background): “Two highly related transcriptional activators, YAP and TAZ, have recently emerged as primary sensors of the cellular microenvironment, integrating cell polarity and mechanical cues with growth factor signaling and inflammation (Piccolo et al., 2014).”
- YAP/TAZ at the roots of cancer (2016, background): “YAP/TAZ orchestrate this crosstalk from both compartments: in epithelial cells, YAP/TAZ favors the secretion of AREG (an EGF-like growth factor), of matricellular proteins such as Cyr61 and CTGF (also known to induce angiogenesis) (Piccolo et al., 2014), and of chemoattractants for T-cell suppressin”
- Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “These findings establish the YAP/TAZ and Hippo pathways as novel determinants of ferroptosis [49,50].”