YAP/TAZ at the roots of cancer

By F. Zanconato, M. Cordenonsi, S. Piccolo. Cancer Cell, 2016

1,782 citations recorded by the source corpus.

Summary YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cells attributes, proliferation, chemoresistance and metastasis. YAP/TAZ are sensors of the structural and mechanical features of the cell microenvironment. A number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling and inhibition of the Hippo pathway. Addiction to YAP/TAZ thus potentially represents a central cancer vulnerability that may be exploited therapeutically.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/3257e175d95ef3c51e758d859fb0a75adf04dbb8

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In Cell Biology

1. Z. Meng
2. Rakesh K. Jain
3. K. Guan
4. X. Trepat
5. David M. Sabatini
6. Thomas Andrew Waigh

Citations in the corpus

• The Hippo Pathway: Biology and Pathophysiology. (2019, background): “Similarly, YAP activation in mice also causes excessive proliferation in multiple tissues (161).”
• Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, neutral): “…activity by favouring its sequestration by the SWI–SNF chromatin-remodelling complex through ARID1A, stiff ECM induces YAP–TAZ to detach from SWI–SNF and to bind to TEAD, unfolding a transcriptional programme and promoting cell proliferation, CSC traits, plasticity and reprogramming 173,212 .”
• Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “Yes-associated protein (YAP) is a mechanosensitive transcriptional regulator with a major role in cancer and other diseases (Moroishi et al., 2015; Plouffe et al., 2015; Zanconato et al., 2016), development (Porazinski et al.”
• The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways (2022, background): “A low signaling through the pathway is associated with cancer initiation, progression, or metastasis (50).”
• Physical traits of cancer (2020, background): “In fibrotic tumors, CAFs are primarily responsible for collagen production, and these cells have more actin stress fibers, alpha smoothmuscle actin, and focal adhesions than nonactivated fibroblasts (14, 98).”