The Hippo Signaling Pathway in Development and Disease

By Yonggang Zheng, Duojia Pan. Developmental Cell, 2019

761 citations recorded by the source corpus.

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/9fe752cad995b1cabde77ad05dbeb51700e23a3e

How researchers see this paper

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1. José A. Guerrero-Martínez
2. Manuel Rodríguez‐Paredes
3. María Ceballos-Chávez
4. E. Gómez-Marín
5. Laura Basurto-Cayuela
6. Qingxiang Zeng
7. Junjiang Liu
8. Jin Yang

Citations in the corpus

• The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways (2022, background): “The Hippo pathway effectors YAP and TAZ are paralogous transcription co-activators that cooperate with TEAD transcription factors to activate genes involved in proliferation and organ growth (Figure 5E) (48,49).”
• Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “Central to this cascade signals from MST1/2 to the oncogenic of transcriptional cofactors YAP1 and its paralog transcriptional coactivator with PDZ-binding motif (TAZ).(263) The major target transcription factors regulated by YAP/TAZ are the TEAD family.”