A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

By M. Aragona, T. Panciera, Andrea Manfrin, S. Giulitti, F. Michielin, N. Elvassore, S. Dupont, S. Piccolo. Cell, 2013

1,578 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2b232a57e72fdfa525b9a51eb48a6dd01fe3e4bf

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Citations in the corpus

YAP/TAZ at the roots of cancer (2016, background): “…regulations making YAP/TAZ phosphorylation by LATS an important yet not an absolute determinant of their nuclear localization or stability (Aragona et al., 2013; Barry et al., 2013; Das et al., 2016; Dupont et al., 2011; Rashidian et al., 2015; Ren et al., 2010; Sorrentino et al., 2014;…”
Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “This is a very nice example of how the mechanical and biochemical (dynamical) control of the actin cytoskeleton is tightly coupled to transcriptional activity, termed a mechanical checkpoint (10).”
The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges (2019, background): “It was revealed that high mechanical stress promotes YAP/TAZ-mediated proliferative activity, whereas low mechanical stress inhibited the activity of YAP/TAZ by F-actin-capping and -severing proteins independent of the Hippo-YAP signaling cascade [163].”
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “Mechanical cues are regulators of Rho-GTPase and ROCK activity, and stiffness changes in the cellular environment have emerged as mediators of TAZ/YAP activity (Aragona et al., 2013; Dupont et al., 2011).”
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “At the mechanical level, YAP is regulated by mechanical cues such as extracellular matrix (ECM) rigidity, strain, shear stress, or adhesive area (Aragona et al., 2013; Benham-Pyle et al., 2015; Calvo et al., 2013; Chaudhuri et al., 2016; Dupont et al., 2011; Elosegui-Artola et al., 2016; Nakajima et”
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (2013, positive): “…in human cancers, mutant YAP/TAZ may not confer a growth advantage because mutant YAP/TAZ may still be kept in check by mechanisms that act independently of LATS, for example by actin mediated regulation of YAP and TAZ 104 , or because they also initiate as yet unknown growth inhibitory mechanisms.”
The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “Mechanically, stabilization of F-actin results in YAP/TAZ activation, while the disruption of F-actin leads to YAP/TAZ inactivation [56].”
Physical traits of cancer (2020, background): “In a two-dimensional (2D) epithelial monolayer model of stretch, cells under tensile stresses showed activation of YAP/TAZ that led to cell proliferation (34) and induced cell cycle entry (22).”
The Hippo Pathway: Biology and Pathophysiology. (2019, background): “The cytoplasmic translocation of YAP/TAZ by high cell confluence involves dynamics of F-actin polymerization and stress fiber formation (64).”
The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “However, LATS1/2-mediated inhibition of YAP/TAZ becomes apparent upon regeneration of the F-actin cytoskeleton (4).”