An LDL-receptor-related protein mediates Wnt signalling in mice

By Kathleen I. Pinson, J. Brennan, S. Monkley, B. Avery, W. Skarnes. Nature, 2000

1,174 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/90e4275b38962ca1786bc29a392dd4ce2ff6fc4d

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In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. K. Guan
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7. P. Beachy
8. S. Angers

Citations in the corpus

• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. (2001, background): “the involvement of LRP-6 and its Drosophila homolog Arrow in the canonical Wnt signaling pathway in Drosophila, Xenopus, and mice (Pinson et al., 2000; Tamai The Interaction of LRP-5 with Axin Is Required for Its Activity et al., 2000; Wehrli et al., 2000).”
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way (2004, background): “In addition to Fz proteins, the canonical Wnt/β -catenin signaling pathway requires single-span transmembrane proteins that belong to a subfamily of low-density-lipoprotein (LDL) receptor related proteins (LRPs): vertebrate Lrp5 and Lrp6, and their Drosophilaortholog Arrow (Pinson et al., 2000; Tama”
• arrow encodes an LDL-receptor-related protein essential for Wingless signalling (2000, background): “Indeed, an insertion in the mouse LRP6 gene has been identified that leads to several Wnt-like phenotype”
• Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. (2004, background): “…transmembrane receptors that partner with members of the frizzled family of seven-pass transmembrane receptors to bind Wnt proteins, forming a functional ligand-receptor complex that activates the canonical Wnt-b-catenin pathway (Pinson et al. 2000; Tamai et al. 2000; Wehrli et al. 2000).”
• Control of osteoblast function and regulation of bone mass (2003, background): “Null mutation of Lrp6 in mice results in loss of Wnt signalling, which is important for many developmental processe”
• Wnt/β-catenin signaling and disease. (2012, positive): “, 2000) and LRP5 and -6 in vertebrates (Pinson et al., 2000; Tamai et al., 2000).”
• Wnt/beta-catenin signaling in development and disease. (2006, positive): “In binding Wnt, Fzs cooperate with a single-pass transmembrane molecule of the LRP family known as Arrow in Drosophila (Wehrli et al., 2000) and LRP5 and -6 in vertebrates (Pinson et al., 2000; Tamai et al., 2000).”
• Osteocytes, mechanosensing and Wnt signaling. (2008, background): “A few years later it was shown that the lowdensity lipoprotein receptor-related protein 6 (Lrp6) knockout (Lrp6-/-) mouse had developmental abnormalities that phenocopied many of the defects observed in mice carrying mutations in Wnt-3a, Wnt-1 or Wnt-7a genes (97).”
• Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor (2002, background): “This sequence homology is consistent with the multiple Wnt deficiency–like phenotypes of Lrp6-deficient mice (Pinson et al., 2000).”