Control of osteoblast function and regulation of bone mass

By S. Harada, G. Rodan. Nature, 2003

1,474 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/8d9048bc7c2ff785231d2c271a913ac6cfcf98e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Massagué
2. P. ten Dijke
3. G. Rodan
4. Osbjorn M. Pearson
5. K. Janssens
6. N. Lee
7. D. Lieberman
8. S. Janssens

In Oncology

1. J. Massagué
2. P. ten Dijke
3. Osbjorn M. Pearson
4. K. Janssens
5. N. Lee
6. D. Lieberman
7. S. Janssens
8. G. Karsenty

In Orthopedics and Sports Medicine

1. Osbjorn M. Pearson
2. D. Lieberman

Citations in the corpus

• The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone. (2004, background): “Leptin, a hormone produced by adipose tissue, may also affect osteoblasts via the hypothalamus through a complex pathway (Harada and Rodan, 2003).”
• Cancer metastasis: building a framework. (2006, background): “Genetic studies have linked Wnt and BMP signals to the differentiation of osteoblasts from bone-marrow mesenchymal precursors, perhaps in part through the induction of Runx2, a “master” transcription factor in the osteoblast lineage (Harada and Rodan, 2003).”
• Endocrine regulation of male fertility by the skeleton. (2011, neutral): “Bone (re)modeling is regulated locally by cytokines produced by bone cells and systemically by hormones and neuropeptides (Harada and Rodan, 2003; Karsenty et al., 2009).”
• Endocrine regulation of energy metabolism by the skeleton. (2007, background): “…of the two bone-specific cell types, 456 Cell 130, 456–469, August 10, 2007 ª2007 Elsevier Inc. osteoblasts and osteoclasts, are determined by secreted molecules that can either be cytokines acting locally or hormones acting systemically (Harada and Rodan, 2003; Teitelbaum and Ross, 2003).”
• Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling (2009, background): “MECHANICAL LOADING IS one of the crucial factors controlling bone mass.((1)) Unloading (reduced me-”
• Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. (2006, background): “Vascularization is a key event during the development of cartilage and bone [16].”
• Transforming Growth Factor- 1 to the Bone (2005, background): “Moreover, bone formation is regulated by endocrine factors such as sex steroid hormones, PTH , 1,25dihydroxyvitamin D3 [1,25-(OH)2D3, the active metabolite of vitamin D], and leptin (104, 105).”