Origin of regulatory T cells with known specificity for antigen

By I. Apostolou, A. Sarukhan, L. Klein, H. von Boehmer. Nature Immunology, 2002

977 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/90001e5262ac122cccc59e729d46a4fa12d09aad

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In Immunology

Citations in the corpus

Foxp3 in control of the regulatory T cell lineage (2007, background): “Foxp3-mediated molecular and functional program The differentiation of the majority of peripheral T reg cells commences in the thymus upon induction of Foxp3 expression in a subset of thymocytes expressing αβ TCRs having increased affinity for self peptide-MHC complexe”
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. (2009, background): “That is, there was no increase in the absolute number of Foxp3+ cells (Apostolou et al., 2002; van Santen et al., 2004).”
In Vivo Instruction of Suppressor Commitment in Naive T Cells (2004, methodology): “previously (2), were coinjected intrasplenically into BALB/c”
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “Although it appears very likely that most CD4 CD25 Treg cell development occurs in the thymus, accumulating evidence suggests that these cells can also develop in the periphery (50, 51), and that they do so under natural conditions, i.”
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1 (2003, background): “Mice engineered to express both a transgenic TCR and its cognate Ag in the thymus have an increased percentage of Tregs in the thymus and the periphery (4, 5), suggesting that Tregs develop from self-reactive T cells that have escaped negative selection.”
Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “In TCR-transgenic systems, high frequencies of CD25 CD4 Tregs were only found if the model antigen was expressed within the thymus (6, 7).”
A two-step process for thymic regulatory T cell development. (2008, background): “Monoclonal TCR transgenic studies suggested that thymic encounter with ‘‘self-antigen’’ expressed as a second transgene facilitates Treg cell development (Apostolou et al., 2002; Jordan et al., 2001).”
CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “Because self-Ags can activate T regulatory cells (38), their role may have been overlooked in artificial systems modeling self-Ags (36).”
Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo (2003, background): “It has previously been shown that although antigen expression on thymic epithelium favors the development of CD25 Tregs (31), expression of antigen by hematopoietic cells in the periphery can induce Tregs that are CD25 (32).”
Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “This is of particular importance given the role that Treg cells play in atherosclerosis, as we recently reported (8, 437; see sect.”
Regulatory T cells, tumour immunity and immunotherapy (2006, background): “Therefore, although it remains controversial, it is possible that T Reg -cell differentiation, expansion and activation are driven in an antigen-specific manne”