Proteomic profiling of exosomes: Current perspectives

By Richard J. Simpson, S. Jensen, Justin W. E. Lim. Proteomics, 2008

853 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3f7aaf5b2f1ca4c51912e140968d9847c41623bd

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Citations in the corpus

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes (2011, background): “Here we show that exosomes—endogenous nano-vesicles that transport RNAs and protein”
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles. (2013, background): “During their biogenesis, EVs are loaded with a variety of biological cargoes, such as cytoskeleton proteins,membrane receptors,mRNAs andmiRNAs [5,6].”
Development of Exosome-encapsulated Paclitaxel to Overcome MDR in Cancer cells (2015, neutral): “They are formed in multivesicular bodies (MVB) inside the cells (5, 12).”
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs (2012, methodology): “Next, extracellular vesicles were subjected to proteomic analysis by mass spectrometry ( Supplementary Table S1 ), which showed that extracellular vesicles contain a number of proteins that were previously identified in microvesicle”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “of ascites, bronchoalveolar lavage fluid, synovial fluid, and breast milk [8,9].”
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission (2011, background): “Exosomes are membrane-bound vesicles of endocytic origin released by numerous cell types and found in abundance in body fluids (Simpson et al., 2008) where they act as natural carriers of mRNA, miRNA and proteins (Schorey and Bhatnagar 2008).”
Exosomes--vesicular carriers for intercellular communication. (2009, background): “Extracellular vesicles such as exosomes, apoptotic blebs, microvesicles, microparticles, prostasomes and prominosomes have been named [1,2].”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, neutral): “Exosomes are nano-vesicles of 50–140 nm in size that contain proteins, mRNA, and microRNAs (miRNAs) protected by a lipid bilayer (Kahlert and Kalluri, 2013; Cocucci et al., 2009; Simons and Raposo, 2009; Simpson et al., 2008; Thé ry et al., 2002).”
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (2017, neutral): “14), and histones are reportedly abundant in exosomes 56,57 (see also Fig.”
Exosomes: extracellular organelles important in intercellular communication. (2010, methodology): “These microvesicles have been studied over the years using a variety of isolation strategies and have been categorized by their distinct structural and biochemical properties [2].”
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. (2015, background): “High-throughput proteomic analyses of exosomes have revealed the presence of extracellular matrix and cell surface proteins such as collagens, integrins, and galectin; cell surface receptors such as platelet-derived growth factor receptor B and epidermal growth factor receptor (EGFR); and signaling ”